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Rspo4 R-spondin 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 499918, updated on 9-Dec-2024

Summary

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Official Symbol
Rspo4provided by RGD
Official Full Name
R-spondin 4provided by RGD
Primary source
RGD:1563415
See related
EnsemblRapid:ENSRNOG00000009662 AllianceGenome:RGD:1563415
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1563415
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within nail development. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in nonsyndromic congenital nail disorder 4. Orthologous to human RSPO4 (R-spondin 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Biased expression in Heart (RPKM 4.1), Lung (RPKM 2.8) and 5 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rspo4 in Genome Data Viewer
Location:
3q41
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (160817611..160852071)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (140357256..140391780)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (147358690..147391719)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486185 Neighboring gene proteasome inhibitor subunit 1 Neighboring gene heterogeneous nuclear ribonucleoprotein H1, pseudogene 2 Neighboring gene uncharacterized LOC120101753 Neighboring gene angiopoietin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in R-spondin 4 (RSPO4) underlie inherited anonychia. Ishii Y, et al. J Invest Dermatol, 2008 Apr. PMID 17805348
  2. The complex world of WNT receptor signalling. Niehrs C. Nat Rev Mol Cell Biol, 2012 Dec. PMID 23151663
  3. RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6. Szenker-Ravi E, et al. Nature, 2018 May. PMID 29769720
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within nail development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
R-spondin-4
Names
R-spondin family, member 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    160817611..160852071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006235262.5 → XP_006235324.1  R-spondin-4 isoform X1

    UniProtKB/TrEMBL
    D4ACX0
    Related
    ENSRNOP00000012951.5, ENSRNOT00000012951.8
    Conserved Domains (2) summary
    smart00261
    Location:85 → 126
    FU; Furin-like repeats
    pfam15913
    Location:35 → 138
    Furin-like_2; Furin-like repeat, cysteine-rich

  2. XM_063285081.1 → XP_063141151.1  R-spondin-4 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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