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Prss44 serine protease 44 [ Rattus norvegicus (Norway rat) ]

Gene ID: 501060, updated on 9-Dec-2024

Summary

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Official Symbol
Prss44provided by RGD
Official Full Name
serine protease 44provided by RGD
Primary source
RGD:1560940
See related
EnsemblRapid:ENSRNOG00000030073 AllianceGenome:RGD:1560940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tessp4; RGD1560940
Summary
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in germ cell development; proteolysis; and spermatogenesis. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to human PRSS44P (serine protease 44, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Restricted expression toward (RPKM 33.8) See more
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Genomic context

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See Prss44 in Genome Data Viewer
Location:
8q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (119670088..119683717)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (110791698..110805303)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (119083900..119097707)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene myosin light chain 3 Neighboring gene serine protease 42 Neighboring gene uncharacterized LOC120094264 Neighboring gene serine protease 44, pseudogene 1 Neighboring gene cAMP-regulated phosphoprotein 19-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Three testis-specific paralogous serine proteases play different roles in murine spermatogenesis and are involved in germ cell survival during meiosis. Yoneda R, et al. Biol Reprod, 2013 May. PMID 23536369
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in germ cell development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine protease 44
Names
protease, serine, 44
testis serine protease 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109298.2 → NP_001102768.2  serine protease 44 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I3H0, E9PSW9
    Related
    ENSRNOP00000044953.4, ENSRNOT00000051947.7

  2. NM_001401228.1 → NP_001388157.1  serine protease 44 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6I3H1, B5DF96, D4A5V1
    Related
    ENSRNOP00000047186.5, ENSRNOT00000048655.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    119670088..119683717
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766648.4 → XP_008764870.1  serine protease 44 isoform X1

    Conserved Domains (2) summary
    smart00020
    Location:10 → 239
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:11 → 239
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Chemical Information
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Research Materials