U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sgsh N-sulfoglucosamine sulfohydrolase [ Rattus norvegicus (Norway rat) ]

Gene ID: 688293, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Symbol
Sgshprovided by RGD
Full Name
N-sulfoglucosamine sulfohydrolaseprovided by RGD
Primary source
RGD:1591134
See related
EnsemblRapid:ENSRNOG00000064880 AllianceGenome:RGD:1591134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable N-sulfoglucosamine sulfohydrolase activity and sulfuric ester hydrolase activity. Predicted to be involved in glycosaminoglycan catabolic process and heparan sulfate proteoglycan catabolic process. Predicted to act upstream of or within determination of adult lifespan and motor behavior. Predicted to be located in lysosome. Predicted to be active in lysosomal lumen. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIIA. Orthologous to human SGSH (N-sulfoglucosamine sulfohydrolase). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Spleen (RPKM 38.2), Adrenal (RPKM 30.3) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Sgsh in Genome Data Viewer
Location:
10q32.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (105095336..105112037, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (104596810..104613510, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (108469312..108479094, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108352165 Neighboring gene eukaryotic translation initiation factor 4A3 Neighboring gene caspase recruitment domain family, member 14 Neighboring gene solute carrier family 26 member 11 Neighboring gene ring finger protein 213 Neighboring gene uncharacterized LOC120095223 Neighboring gene endonuclease V

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Transport, enzymatic activity, and stability of mutant sulfamidase (SGSH) identified in patients with mucopolysaccharidosis type III A. Muschol N, et al. Hum Mutat, 2004 Jun. PMID 15146460
  2. Cloning of the sulphamidase gene and identification of mutations in Sanfilippo A syndrome. Scott HS, et al. Nat Genet, 1995 Dec. PMID 7493035
  3. Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2. Zito E, et al. EMBO Rep, 2005 Jul. PMID 15962010, Free PMC Article
  4. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-sulfoglucosamine sulfohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-sulfoglucosamine sulfohydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables sulfuric ester hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within determination of adult lifespan ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosaminoglycan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycosaminoglycan catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heparan sulfate proteoglycan catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparan sulfate proteoglycan catabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within motor behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in lysosomal lumen ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
N-sulphoglucosamine sulphohydrolase
NP_001413999.1
XP_038943466.1
XP_038943467.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427070.2 → NP_001413999.1  N-sulphoglucosamine sulphohydrolase precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZZ84
    Related
    ENSRNOP00000084506.1, ENSRNOT00000098505.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    105095336..105112037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039087538.2 → XP_038943466.1  N-sulphoglucosamine sulphohydrolase isoform X1

    Conserved Domains (1) summary
    cl23718
    Location:24 → 404
    ALP_like; alkaline phosphatases and sulfatases

  2. XM_039087539.2 → XP_038943467.1  N-sulphoglucosamine sulphohydrolase isoform X2

    UniProtKB/TrEMBL
    A0A8I6A071
    Related
    ENSRNOP00000084730.1, ENSRNOT00000093976.2
    Conserved Domains (1) summary
    cl23718
    Location:1 → 227
    ALP_like; alkaline phosphatases and sulfatases
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.