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    Rnpep arginyl aminopeptidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81761, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnpepprovided by RGD
    Official Full Name
    arginyl aminopeptidaseprovided by RGD
    Primary source
    RGD:621137
    See related
    EnsemblRapid:ENSRNOG00000006720 AllianceGenome:RGD:621137
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables metalloaminopeptidase activity; peptide binding activity; and transition metal ion binding activity. Involved in negative regulation of blood pressure; protein processing; and retina development in camera-type eye. Located in external side of plasma membrane; extracellular space; and secretory granule. Used to study hypertension. Biomarker of hypertension. Orthologous to human RNPEP (arginyl aminopeptidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 140.6), Testes (RPKM 139.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rnpep in Genome Data Viewer
    Location:
    13q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (49251259..49271440, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (46699458..46717829, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (52092863..52124006, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 37-like 1 Neighboring gene E74 like ETS transcription factor 3 Neighboring gene translocase of inner mitochondrial membrane 17A Neighboring gene uncharacterized LOC120096253 Neighboring gene leiomodin 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aminopeptidase activity PubMed 
    enables cobalt ion binding PubMed 
    enables copper ion binding PubMed 
    enables metalloaminopeptidase activity  
    enables metalloaminopeptidase activity PubMed 
    enables metallopeptidase activity  
    enables peptide binding PubMed 
    enables zinc ion binding PubMed 
    enables zinc ion binding  
    enables zinc ion binding PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of blood pressure PubMed 
    involved_in protein processing PubMed 
    involved_in protein processing PubMed 
    involved_in proteolysis  
    involved_in proteolysis PubMed 
    involved_in proteolysis  
    involved_in retina development in camera-type eye PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in external side of plasma membrane PubMed 
    located_in extracellular region PubMed 
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in plasma membrane PubMed 
    located_in secretory granule PubMed 

    General protein information

    Preferred Names
    aminopeptidase B
    Names
    AP-B
    arginine aminopeptidase
    cytosol aminopeptidase IV
    NP_112359.2
    XP_063128706.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429661.1NP_001416590.1  aminopeptidase B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6GJU0, Q6P7D2
    2. NM_031097.2NP_112359.2  aminopeptidase B isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6ICE6, G3V6V1, Q6P7D2
      Related
      ENSRNOP00000009198.3, ENSRNOT00000009198.7
      Conserved Domains (2) summary
      cd09599
      Location:24484
      M1_LTA4H; Peptidase M1 family including Leukotriene A4 hydrolase catalytic domain
      pfam09127
      Location:530645
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      49251259..49271440 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272636.1XP_063128706.1  aminopeptidase B isoform X1

      UniProtKB/TrEMBL
      A6ICE6, G3V6V1, Q6P7D2
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