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    Rala RAS like proto-oncogene A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81757, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ralaprovided by RGD
    Official Full Name
    RAS like proto-oncogene Aprovided by RGD
    Primary source
    RGD:619851
    See related
    EnsemblRapid:ENSRNOG00000013454 AllianceGenome:RGD:619851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including Edg-2 lysophosphatidic acid receptor binding activity; enzyme binding activity; and guanyl ribonucleotide binding activity. Involved in regulation of postsynaptic neurotransmitter receptor internalization. Is active in Schaffer collateral - CA1 synapse and synaptic membrane. Orthologous to human RALA (RAS like proto-oncogene A). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 118.4), Brain (RPKM 109.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rala in Genome Data Viewer
    Location:
    17q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (51787682..51840738)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (47092163..47145192)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (49676073..49729133)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene ADP-ribosylation factor 1, pseudogene 1 Neighboring gene phosphoglycerate mutase 1, pseudogene 5 Neighboring gene cyclin-dependent kinase 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATPase binding  
    enables Edg-2 lysophosphatidic acid receptor binding  
    enables Edg-2 lysophosphatidic acid receptor binding  
    enables G protein activity  
    enables GDP binding  
    enables GDP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTP binding  
    enables GTP binding PubMed 
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables myosin binding  
    enables protein binding PubMed 
    enables ubiquitin protein ligase binding  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction  
    involved_in Ras protein signal transduction  
    involved_in cell division  
    involved_in establishment of protein localization to mitochondrion  
    involved_in establishment of protein localization to mitochondrion  
    involved_in exocytosis  
    involved_in membrane raft localization  
    involved_in membrane raft localization  
    involved_in neural tube closure  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway  
    involved_in positive regulation of filopodium assembly  
    involved_in positive regulation of mitochondrial fission  
    involved_in positive regulation of mitochondrial fission  
    involved_in receptor internalization  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of exocytosis  
    involved_in regulation of exocytosis  
    involved_in regulation of exocytosis  
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in signal transduction  
    Component Evidence Code Pubs
    located_in Flemming body  
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    is_active_in Schaffer collateral - CA1 synapse PubMed 
    located_in cell surface  
    located_in cleavage furrow  
    located_in cleavage furrow  
    located_in cytosol  
    located_in endocytic vesicle  
    located_in endomembrane system  
    located_in focal adhesion  
    located_in focal adhesion  
    located_in membrane  
    located_in mitochondrion  
    located_in mitochondrion  
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in synaptic membrane PubMed 

    General protein information

    Preferred Names
    ras-related protein Ral-A
    Names
    RALA Ras like proto-oncogene A
    v-ral simian leukemia viral oncogene homolog A (ras related)
    NP_001401109.1
    NP_112355.1
    XP_038952038.1
    XP_038952040.1
    XP_063132843.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414180.2NP_001401109.1  ras-related protein Ral-A

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      P63322
      UniProtKB/TrEMBL
      A0A8L2Q942, A6K9A2
      Related
      ENSRNOP00000090376.2, ENSRNOT00000102020.2
    2. NM_031093.4NP_112355.1  ras-related protein Ral-A

      See identical proteins and their annotated locations for NP_112355.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/Swiss-Prot
      P63322
      UniProtKB/TrEMBL
      A0A8L2Q942, A6K9A2
      Related
      ENSRNOP00000018190.4, ENSRNOT00000018190.6
      Conserved Domains (1) summary
      cd04139
      Location:15177
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      51787682..51840738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276773.1XP_063132843.1  ras-related protein Ral-A isoform X2

    2. XM_039096112.2XP_038952040.1  ras-related protein Ral-A isoform X1

      UniProtKB/Swiss-Prot
      P63322
      UniProtKB/TrEMBL
      A0A8L2Q942, A6K9A2
      Conserved Domains (1) summary
      cd04139
      Location:15177
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
    3. XM_039096110.2XP_038952038.1  ras-related protein Ral-A isoform X1

      UniProtKB/Swiss-Prot
      P63322
      UniProtKB/TrEMBL
      A0A8L2Q942, A6K9A2
      Conserved Domains (1) summary
      cd04139
      Location:15177
      RalA_RalB; Ral (Ras-like) family containing highly homologous RalA and RalB
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