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    Meox2 mesenchyme homeobox 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29279, updated on 9-Dec-2024

    Summary

    Official Symbol
    Meox2provided by RGD
    Official Full Name
    mesenchyme homeobox 2provided by RGD
    Primary source
    RGD:3079
    See related
    EnsemblRapid:ENSRNOG00000006588 AllianceGenome:RGD:3079
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in fibroblast proliferation and myofibroblast differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Biomarker of myocardial infarction. Orthologous to human MEOX2 (mesenchyme homeobox 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 146.5), Muscle (RPKM 118.8) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Meox2 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (59584025..59644722)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (53856760..53917467)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (56625768..56689195)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 2 Neighboring gene small nucleolar RNA U3 Neighboring gene exosome component 4, pseudogene 1 Neighboring gene alkylglycerol monooxygenase Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in angiogenesis  
    acts_upstream_of_or_within angiogenesis  
    involved_in fibroblast proliferation PubMed 
    involved_in limb development  
    acts_upstream_of_or_within limb development  
    involved_in myofibroblast differentiation PubMed 
    involved_in negative regulation of cell migration involved in sprouting angiogenesis  
    involved_in negative regulation of cell migration involved in sprouting angiogenesis  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in roof of mouth development  
    acts_upstream_of_or_within roof of mouth development  
    involved_in skeletal muscle tissue development  
    acts_upstream_of_or_within skeletal muscle tissue development  
    involved_in somite development  
    involved_in somite specification  
    acts_upstream_of_or_within somite specification  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytoplasm  
    located_in nuclear speck  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    homeobox protein MOX-2
    Names
    growth arrest-specific homeobox
    mesenchyme homeo box 2 (growth arrest-specific homeo box)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017149.2NP_058845.2  homeobox protein MOX-2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P39020
      UniProtKB/TrEMBL
      A6HBB5, G3V6T9
      Related
      ENSRNOP00000008803.1, ENSRNOT00000008803.5
      Conserved Domains (1) summary
      pfam00046
      Location:190243
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      59584025..59644722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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