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    Plaa phospholipase A2, activating protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116645, updated on 9-Dec-2024

    Summary

    Official Symbol
    Plaaprovided by RGD
    Official Full Name
    phospholipase A2, activating proteinprovided by RGD
    Primary source
    RGD:621245
    See related
    EnsemblRapid:ENSRNOG00000007753 AllianceGenome:RGD:621245
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Plap; PLA2P
    Summary
    Predicted to enable phospholipase A2 activator activity and ubiquitin binding activity. Predicted to be involved in several processes, including negative regulation of protein K63-linked ubiquitination; positive regulation of dendrite extension; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within inflammatory response. Predicted to be located in extracellular exosome and synapse. Predicted to be active in cytoplasm and nucleus. Orthologous to human PLAA (phospholipase A2 activating protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 239.3), Heart (RPKM 232.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Plaa in Genome Data Viewer
    Location:
    5q33
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (114544327..114576023, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (109428600..109460373, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (113548913..113578928, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene large ribosomal subunit protein uL2-like Neighboring gene uncharacterized LOC120102920 Neighboring gene caspase activity and apoptosis inhibitor 1 Neighboring gene intraflagellar transport 74 Neighboring gene leucine rich repeat containing 19 Neighboring gene microRNA 872

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phospholipase A2 activator activity  
    enables ubiquitin binding  
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide  
    involved_in cellular response to lipopolysaccharide  
    acts_upstream_of_or_within inflammatory response  
    involved_in macroautophagy  
    involved_in macroautophagy  
    involved_in negative regulation of protein K63-linked ubiquitination  
    involved_in negative regulation of protein K63-linked ubiquitination  
    involved_in nervous system development  
    involved_in positive regulation of dendrite extension  
    involved_in positive regulation of dendrite extension  
    involved_in positive regulation of neuron migration  
    involved_in positive regulation of neuron migration  
    involved_in positive regulation of phospholipase A2 activity  
    involved_in positive regulation of phospholipase A2 activity  
    involved_in positive regulation of synaptic vesicle recycling  
    involved_in positive regulation of synaptic vesicle recycling  
    involved_in prostaglandin metabolic process  
    involved_in prostaglandin metabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in ubiquitin recycling  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in extracellular exosome  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in synapse  
    located_in synapse  

    General protein information

    Preferred Names
    phospholipase A-2-activating protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053866.3NP_446318.3  phospholipase A-2-activating protein

      See identical proteins and their annotated locations for NP_446318.3

      Status: VALIDATED

      Source sequence(s)
      BP498567, CB701630, CF110238, CK366206, CV109083, CV110320
      UniProtKB/Swiss-Prot
      P54319
      UniProtKB/TrEMBL
      A6JRG3, A6JRG5
      Conserved Domains (4) summary
      cd00200
      Location:10297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:69110
      7WD40; WD40 repeat [structural motif]
      pfam08324
      Location:536789
      PUL; PUL domain
      pfam09070
      Location:346459
      PFU; PFU (PLAA family ubiquitin binding)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      114544327..114576023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109151.2XP_038965079.1  phospholipase A-2-activating protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6A2M3, A6JRG3, A6JRG4
      Related
      ENSRNOP00000085067.1, ENSRNOT00000094582.2
      Conserved Domains (4) summary
      cd00200
      Location:10297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:69110
      7WD40; WD40 repeat [structural motif]
      pfam08324
      Location:513766
      PUL; PUL domain
      pfam09070
      Location:346459
      PFU; PFU (PLAA family ubiquitin binding)
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