Snx6 sorting nexin 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Snx6provided by RGD
Official Full Name: sorting nexin 6provided by RGD
Primary source: RGD:1304647
See related: EnsemblRapid:ENSRNOG00000005249 AllianceGenome:RGD:1304647
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable dynactin binding activity; protein homodimerization activity; and type I transforming growth factor beta receptor binding activity. Involved in cellular response to epidermal growth factor stimulus. Located in endosome. Orthologous to human SNX6 (sorting nexin 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 459.2), Lung (RPKM 224.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q23

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (77966141..78009343, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (72230950..72274157, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (75626927..75670172, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_10231-10232:998405705:1 (e-PCR)
- UniSTS:267077

RH129893 (e-PCR)
- UniSTS:213181

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynactin binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynactin binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables type I transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epidermal growth factor stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of histamine secretion by mast cell	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic early endosome	ISO Inferred from Sequence Orthology more info
part_of retromer complex	ISO Inferred from Sequence Orthology more info
located_in tubular endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sorting nexin-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108711.1 → NP_001102181.1 sorting nexin-6

See identical proteins and their annotated locations for NP_001102181.1

Status: PROVISIONAL

Source sequence(s)

CH473947

UniProtKB/TrEMBL

A0A8I5ZS69, B5DEY8

Related

ENSRNOP00000081270.2, ENSRNOT00000117817.2

Conserved Domains (2) summary

cd07292
Location:30 → 170

PX_SNX6; The phosphoinositide binding Phox Homology domain of Sorting Nexin 6

cd07662
Location:186 → 403

BAR_SNX6; The Bin/Amphiphysin/Rvs (BAR) domain of Sorting Nexin 6