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    Stat2 signal transducer and activator of transcription 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288774, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stat2provided by RGD
    Official Full Name
    signal transducer and activator of transcription 2provided by RGD
    Primary source
    RGD:1311649
    See related
    EnsemblRapid:ENSRNOG00000031081 AllianceGenome:RGD:1311649
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and ubiquitin-like protein ligase binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; defense response to symbiont; and negative regulation of type I interferon-mediated signaling pathway. Predicted to be located in cytosol and plasma membrane. Predicted to be part of ISGF3 complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Zika fever; immunodeficiency 44; and neutropenia. Orthologous to human STAT2 (signal transducer and activator of transcription 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 238.2), Liver (RPKM 235.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Stat2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1287025..1302858)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (702565..718349)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2691064..2707530)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene apolipoprotein N Neighboring gene apolipoprotein F Neighboring gene interleukin 23 subunit alpha Neighboring gene poly(A) specific ribonuclease subunit PAN2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process  
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    involved_in cell surface receptor signaling pathway via JAK-STAT  
    involved_in defense response  
    involved_in defense response to virus  
    involved_in negative regulation of type I interferon-mediated signaling pathway  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of cell population proliferation  
    involved_in regulation of mitochondrial fission  
    involved_in regulation of protein phosphorylation  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in regulation of transcription by RNA polymerase II  
    involved_in response to peptide hormone  
    involved_in type I interferon-mediated signaling pathway  
    involved_in type I interferon-mediated signaling pathway  
    Component Evidence Code Pubs
    part_of ISGF3 complex  
    part_of ISGF3 complex  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in nucleus  
    is_active_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    signal transducer and activator of transcription 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011905.1NP_001011905.1  signal transducer and activator of transcription 2

      See identical proteins and their annotated locations for NP_001011905.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083867
      UniProtKB/TrEMBL
      F7EYG9, Q5XI26
      Related
      ENSRNOP00000075125.3, ENSRNOT00000088201.3
      Conserved Domains (5) summary
      cd10373
      Location:556706
      SH2_STAT2; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 2 proteins
      smart00964
      Location:2123
      STAT_int; STAT protein, protein interaction domain
      pfam01017
      Location:142315
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:317565
      STAT_bind; STAT protein, DNA binding domain
      pfam12188
      Location:774829
      STAT2_C; Signal transducer and activator of transcription 2 C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1287025..1302858
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263091.1XP_063119161.1  signal transducer and activator of transcription 2 isoform X3

      UniProtKB/TrEMBL
      F7EYG9
    2. XM_063263089.1XP_063119159.1  signal transducer and activator of transcription 2 isoform X1

      UniProtKB/TrEMBL
      F7EYG9
    3. XM_063263090.1XP_063119160.1  signal transducer and activator of transcription 2 isoform X2

      UniProtKB/TrEMBL
      F7EYG9
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