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    Mypn myopalladin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309760, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mypnprovided by RGD
    Official Full Name
    myopalladinprovided by RGD
    Primary source
    RGD:1308510
    See related
    EnsemblRapid:ENSRNOG00000000383 AllianceGenome:RGD:1308510
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SH3 domain binding activity and muscle alpha-actinin binding activity. Predicted to be involved in cell-cell adhesion and sarcomere organization. Located in Z disc and nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy 1KK and nemaline myopathy 11. Orthologous to human MYPN (myopalladin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 549.7) and Heart (RPKM 174.6) See more
    Orthologs
    NEW
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    Genomic context

    See Mypn in Genome Data Viewer
    Location:
    20p11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (25435554..25521149)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (25429898..25522443)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (26988820..27074106)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 4 Neighboring gene mitochondrial ribosomal protein S36, pseudogene 1 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene ribosomal protein L29, pseudogene 22 Neighboring gene atonal bHLH transcription factor 7

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables muscle alpha-actinin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in I band IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in I band ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in Z disc ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368817.1NP_001355746.1  myopalladin

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A0G2K046, A6JKZ0, D4A7X7
      Related
      ENSRNOP00000071299.1, ENSRNOT00000090083.3
      Conserved Domains (2) summary
      pfam07679
      Location:10591149
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:11751249
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      25435554..25521149
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107628.1: Suppressed sequence

      Description
      NM_001107628.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from zebrafish: mypn (GeneID:571695).