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    Metap1d methionyl aminopeptidase type 1D (mitochondrial) [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311748, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Metap1dprovided by RGD
    Official Full Name
    methionyl aminopeptidase type 1D (mitochondrial)provided by RGD
    Primary source
    RGD:1307413
    See related
    EnsemblRapid:ENSRNOG00000061587 AllianceGenome:RGD:1307413
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Map1d; Metapl1
    Summary
    Predicted to enable metalloaminopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in mitochondrion. Orthologous to human METAP1D (methionyl aminopeptidase type 1D, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 29.1), Adrenal (RPKM 25.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Metap1d in Genome Data Viewer
    Location:
    3q23
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (76687149..76759681)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (56279471..56354518)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (58084558..58160748)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene histone acetyltransferase 1 Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC102549016 Neighboring gene uncharacterized LOC108350393 Neighboring gene distal-less homeobox 1 Neighboring gene distal-less homeobox 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An unusual peptide deformylase features in the human mitochondrial N-terminal methionine excision pathway. Serero A, et al. J Biol Chem, 2003 Dec 26. PMID 14532271
    2. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables initiator methionyl aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    methionine aminopeptidase 1D, mitochondrial
    Names
    methionine aminopeptidase-like 1
    NP_001101282.2
    XP_038961094.1
    XP_038961096.1
    XP_038961097.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107812.2 → NP_001101282.2  methionine aminopeptidase 1D, mitochondrial

      See identical proteins and their annotated locations for NP_001101282.2

      Status: VALIDATED

      Source sequence(s)
      BC167092, DY575699
      UniProtKB/TrEMBL
      A6HM49, B2RZB4, G3V670
      Related
      ENSRNOP00000072048.1, ENSRNOT00000084797.3
      Conserved Domains (1) summary
      cd01086
      Location:93 → 329
      MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      76687149..76759681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039105166.2 → XP_038961094.1  methionine aminopeptidase 1D, mitochondrial isoform X1

      UniProtKB/TrEMBL
      B2RZB4
      Conserved Domains (1) summary
      cd01086
      Location:65 → 279
      MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

    2. XM_039105169.2 → XP_038961097.1  methionine aminopeptidase 1D, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A6HM50
      Conserved Domains (1) summary
      PLN03158
      Location:54 → 179
      PLN03158; methionine aminopeptidase; Provisional

    3. XM_039105168.2 → XP_038961096.1  methionine aminopeptidase 1D, mitochondrial isoform X2

      Conserved Domains (1) summary
      cd01086
      Location:1 → 212
      MetAP1; Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.

    RNA

    1. XR_005501905.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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