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    Impact impact RWD domain protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497198, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Impactprovided by RGD
    Official Full Name
    impact RWD domain proteinprovided by RGD
    Primary source
    RGD:1591977
    See related
    EnsemblRapid:ENSRNOG00000045844 AllianceGenome:RGD:1591977
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity; protein sequestering activity; and ribosome binding activity. Predicted to be involved in several processes, including GCN2-mediated signaling; cellular response to amino acid starvation; and regulation of gene expression. Predicted to act upstream of or within negative regulation of protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human IMPACT (impact RWD domain protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 814.8), Thymus (RPKM 267.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Impact in Genome Data Viewer
    Location:
    18p13
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (4383546..4422280)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (4108872..4147571)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (4325872..4346734)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 1A Neighboring gene uncharacterized LOC102546723 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene uncharacterized LOC134482907 Neighboring gene histamine receptor H4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative genomics approach toward critical determinants for the imprinting of an evolutionarily conserved gene Impact. Okamura K, et al. Biochem Biophys Res Commun, 2005 Apr 15. PMID 15752730
    2. IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2α kinase GCN2 in the modulation of neurite outgrowth. Roffé M, et al. J Biol Chem, 2013 Apr 12. PMID 23447528, Free PMC Article
    3. Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2. Cambiaghi TD, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24333428
    4. Evidence that Yih1 resides in a complex with ribosomes. Waller T, et al. FEBS J, 2012 May. PMID 22404850
    5. Physiological Tau Interactome in Brain and Its Link to Tauopathies. Sinsky J, et al. J Proteome Res, 2020 Jun 5. PMID 32357304

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein sequestering activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in GCN2-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GCN2-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in GCN2-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cellular response to amino acid starvation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to amino acid starvation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neuron projection extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection extension ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cytoplasmic translational initiation in response to stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytoplasmic translational initiation in response to stress ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protein IMPACT
    Names
    imprinted and ancient gene protein homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012235.1 → NP_001012235.1  protein IMPACT

      See identical proteins and their annotated locations for NP_001012235.1

      Status: PROVISIONAL

      Source sequence(s)
      AY574213
      UniProtKB/Swiss-Prot
      Q5GFD9
      UniProtKB/TrEMBL
      A0A8L2QV96, A6KLS9
      Related
      ENSRNOP00000102236.1, ENSRNOT00000121832.1
      Conserved Domains (2) summary
      smart00591
      Location:15 → 115
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam01205
      Location:180 → 285
      UPF0029; Uncharacterized protein family UPF0029

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      4383546..4422280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277509.1 → XP_063133579.1  protein IMPACT isoform X1

      UniProtKB/Swiss-Prot
      Q5GFD9
      UniProtKB/TrEMBL
      A0A8L2QV96, A6KLS9

    2. XM_063277511.1 → XP_063133581.1  protein IMPACT isoform X1

      UniProtKB/Swiss-Prot
      Q5GFD9
      UniProtKB/TrEMBL
      A0A8L2QV96, A6KLS9

    3. XM_063277510.1 → XP_063133580.1  protein IMPACT isoform X1

      UniProtKB/Swiss-Prot
      Q5GFD9
      UniProtKB/TrEMBL
      A0A8L2QV96, A6KLS9

    4. XM_063277512.1 → XP_063133582.1  protein IMPACT isoform X1

      UniProtKB/Swiss-Prot
      Q5GFD9
      UniProtKB/TrEMBL
      A0A8L2QV96, A6KLS9

    5. XM_039097018.2 → XP_038952946.1  protein IMPACT isoform X1

      UniProtKB/Swiss-Prot
      Q5GFD9
      UniProtKB/TrEMBL
      A0A8L2QV96, A6KLS9
      Related
      ENSRNOP00000078372.1, ENSRNOT00000116602.2
      Conserved Domains (2) summary
      smart00591
      Location:15 → 115
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam01205
      Location:180 → 285
      UPF0029; Uncharacterized protein family UPF0029
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5GFD9.1 GenPept UniProtKB/Swiss-Prot:Q5GFD9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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