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    Hepacam hepatic and glial cell adhesion molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300517, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hepacamprovided by RGD
    Official Full Name
    hepatic and glial cell adhesion moleculeprovided by RGD
    Primary source
    RGD:1306811
    See related
    EnsemblRapid:ENSRNOG00000009219 AllianceGenome:RGD:1306811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306811
    Summary
    Predicted to be involved in protein localization to cell-cell junction. Predicted to act upstream of or within protein localization. Predicted to be located in astrocyte end-foot; cell-cell junction; and membrane. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts 2A and megalencephalic leukoencephalopathy with subcortical cysts 2B. Orthologous to human HEPACAM (hepatic and glial cell adhesion molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 39.0), Testes (RPKM 4.4) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hepacam in Genome Data Viewer
    Location:
    8q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (45276594..45294006)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (37087864..37106759)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39848264..39866969)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 37 member 2 Neighboring gene coiled-coil domain containing 15 Neighboring gene transfer RNA proline (anticodon AGG) 64 Neighboring gene uncharacterized LOC120094115 Neighboring gene roundabout guidance receptor 4 Neighboring gene roundabout guidance receptor 3 Neighboring gene uncharacterized LOC102549473 Neighboring gene Myb/SANT DNA binding domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HepaCAM controls astrocyte self-organization and coupling. Baldwin KT, et al. Neuron, 2021 Aug 4. PMID 34171291, Free PMC Article
    2. Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism. López-Hernández T, et al. Am J Hum Genet, 2011 Apr 8. PMID 21419380, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HepaCAM controls astrocyte self-organization and coupling.
      Title: HepaCAM controls astrocyte self-organization and coupling.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in astrocyte end-foot ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    hepatic and glial cell adhesion molecule
    Names
    hepatocyte cell adhesion molecule

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429434.1 → NP_001416363.1  hepatic and glial cell adhesion molecule isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6B3X3, D3ZEI4

    2. NM_001429435.1 → NP_001416364.1  hepatic and glial cell adhesion molecule isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D3ZEI4

    3. NM_001429436.1 → NP_001416365.1  hepatic and glial cell adhesion molecule isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      45276594..45294006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082304.2 → XP_038938232.1  hepatic and glial cell adhesion molecule isoform X1

      Related
      ENSRNOP00000096251.1, ENSRNOT00000107950.2
      Conserved Domains (3) summary
      cl29975
      Location:324 → 383
      Herpes_UL1; Herpesvirus glycoprotein L
      cd00096
      Location:43 → 45
      Ig; Ig strand A [structural motif]
      cl11960
      Location:43 → 141
      Ig; Immunoglobulin domain

    2. XM_063266297.1 → XP_063122367.1  hepatic and glial cell adhesion molecule isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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