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    Insr insulin receptor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24954, updated on 9-Dec-2024

    Summary

    Official Symbol
    Insrprovided by RGD
    Official Full Name
    insulin receptorprovided by RGD
    Primary source
    RGD:2917
    See related
    EnsemblRapid:ENSRNOG00000029986 AllianceGenome:RGD:2917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including enzyme binding activity; insulin binding activity; and insulin receptor activity. Involved in several processes, including negative regulation of macromolecule metabolic process; neuron projection organization; and protein phosphorylation. Located in several cellular components, including dendrite membrane; external side of plasma membrane; and neuronal cell body membrane. Used to study chronic kidney disease; diabetic neuropathy; liver disease (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including Alzheimer's disease; diabetes mellitus (multiple); hepatic encephalopathy; liver disease (multiple); and short bowel syndrome. Human ortholog(s) of this gene implicated in Donohue syndrome; glucose metabolism disease (multiple); and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 142.4), Adrenal (RPKM 139.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Insr in Genome Data Viewer
    Location:
    12p12
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (5991135..6129275, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (1193193..1330976, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (1682527..1816414, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 5S ribosomal RNA Neighboring gene 5S ribosomal RNA Neighboring gene uncharacterized LOC134481143 Neighboring gene uncharacterized LOC134481144 Neighboring gene Rho/Rac guanine nucleotide exchange factor 18 Neighboring gene uncharacterized LOC120095867 Neighboring gene peroxisomal biogenesis factor 11 gamma Neighboring gene stabilizer of axonemal microtubules 5

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 56
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase binding PubMed 
    enables ATP binding  
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables GTP binding  
    enables PTB domain binding  
    enables amyloid-beta binding  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables cargo receptor activity PubMed 
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables identical protein binding  
    enables insulin binding PubMed 
    enables insulin binding PubMed 
    enables insulin binding  
    enables insulin receptor activity  
    enables insulin receptor activity PubMed 
    enables insulin receptor activity  
    enables insulin receptor activity PubMed 
    enables insulin receptor activity  
    enables insulin receptor substrate binding  
    enables insulin receptor substrate binding  
    enables insulin receptor substrate binding PubMed 
    enables insulin receptor substrate binding  
    enables insulin-like growth factor I binding  
    enables insulin-like growth factor II binding  
    enables insulin-like growth factor receptor activity  
    enables insulin-like growth factor receptor binding  
    enables lipoic acid binding PubMed 
    enables macrophage colony-stimulating factor receptor activity  
    enables phosphatidylinositol 3-kinase binding  
    enables phosphatidylinositol 3-kinase binding  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein domain specific binding  
    enables protein kinase activator activity  
    enables protein kinase activity PubMed 
    enables protein kinase binding PubMed 
    enables protein phosphatase binding PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables protein-containing complex binding PubMed 
    enables protein-containing complex binding  
    enables stem cell factor receptor activity  
    enables structural molecule activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 56
    Items 1 - 25 of 121
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway  
    involved_in Kit signaling pathway  
    involved_in activation of protein kinase B activity  
    involved_in adrenal gland development  
    involved_in adrenal gland development  
    involved_in amyloid-beta clearance PubMed 
    involved_in animal organ morphogenesis  
    acts_upstream_of_or_within animal organ morphogenesis  
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    acts_upstream_of_or_within cellular response to growth factor stimulus  
    involved_in cellular response to insulin stimulus  
    involved_in cellular response to zinc ion starvation PubMed 
    involved_in cerebellum development PubMed 
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in dendritic spine maintenance PubMed 
    involved_in embryonic liver development PubMed 
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in epidermis development  
    acts_upstream_of_or_within epidermis development  
    involved_in exocrine pancreas development  
    acts_upstream_of_or_within exocrine pancreas development  
    involved_in fat cell differentiation PubMed 
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in glucose homeostasis  
    involved_in glucose homeostasis  
    involved_in heart morphogenesis  
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in hippocampus development PubMed 
    involved_in insulin receptor signaling pathway PubMed 
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway PubMed 
    involved_in insulin receptor signaling pathway PubMed 
    acts_upstream_of_or_within insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in liver development PubMed 
    involved_in liver regeneration PubMed 
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in male gonad development  
    involved_in male gonad development  
    involved_in male sex determination  
    acts_upstream_of_or_within male sex determination  
    involved_in multicellular organism development  
    involved_in negative regulation of feeding behavior PubMed 
    involved_in negative regulation of gene expression PubMed 
    involved_in negative regulation of glycogen biosynthetic process PubMed 
    involved_in negative regulation of protein phosphorylation PubMed 
    involved_in negative regulation of transporter activity PubMed 
    involved_in neuron projection maintenance PubMed 
    acts_upstream_of_or_within peptidyl-tyrosine autophosphorylation  
    involved_in peptidyl-tyrosine phosphorylation PubMed 
    involved_in peptidyl-tyrosine phosphorylation  
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of D-glucose import  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    acts_upstream_of positive regulation of MAP kinase activity  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of developmental growth  
    involved_in positive regulation of glycogen biosynthetic process  
    acts_upstream_of positive regulation of glycogen biosynthetic process  
    involved_in positive regulation of glycogen biosynthetic process  
    involved_in positive regulation of glycolytic process  
    involved_in positive regulation of glycoprotein biosynthetic process PubMed 
    involved_in positive regulation of meiotic cell cycle  
    involved_in positive regulation of meiotic cell cycle  
    involved_in positive regulation of mitotic nuclear division  
    acts_upstream_of_or_within positive regulation of mitotic nuclear division  
    involved_in positive regulation of mitotic nuclear division  
    involved_in positive regulation of nitric oxide biosynthetic process  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphorylation PubMed 
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of protein-containing complex disassembly PubMed 
    involved_in positive regulation of receptor internalization  
    involved_in positive regulation of respiratory burst  
    involved_in protein autophosphorylation PubMed 
    involved_in protein autophosphorylation PubMed 
    involved_in protein autophosphorylation  
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in receptor internalization  
    acts_upstream_of_positive_effect receptor internalization  
    involved_in receptor-mediated endocytosis PubMed 
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of embryonic development  
    involved_in regulation of female gonad development  
    involved_in regulation of female gonad development  
    involved_in regulation of gluconeogenesis PubMed 
    involved_in regulation of hydrogen peroxide metabolic process PubMed 
    involved_in response to activity PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to ethanol PubMed 
    involved_in response to food PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to glucose PubMed 
    involved_in response to hormone PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to insulin PubMed 
    involved_in response to manganese ion PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to nutrient levels PubMed 
    involved_in response to resveratrol PubMed 
    involved_in response to starvation PubMed 
    involved_in response to testosterone PubMed 
    involved_in response to tumor necrosis factor PubMed 
    involved_in response to vanadate(3-) PubMed 
    involved_in response to vitamin D PubMed 
    involved_in symbiont entry into host cell  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 121
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    is_active_in axon  
    located_in caveola  
    located_in caveola  
    located_in cell body PubMed 
    located_in dendrite PubMed 
    located_in dendrite membrane PubMed 
    located_in endosome PubMed 
    located_in external side of plasma membrane PubMed 
    part_of insulin receptor complex  
    part_of insulin receptor complex  
    located_in late endosome  
    located_in lysosome  
    located_in membrane  
    located_in membrane  
    located_in neuronal cell body PubMed 
    located_in neuronal cell body membrane PubMed 
    located_in nuclear envelope  
    located_in nuclear lumen  
    is_active_in plasma membrane  
    is_active_in plasma membrane  
    located_in plasma membrane  
    part_of receptor complex  
    located_in yolk PubMed 
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    insulin receptor
    Names
    IR
    insulin receptor preproprotein
    NP_058767.2
    XP_038945024.1
    XP_038945025.1
    XP_063127138.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017071.2NP_058767.2  insulin receptor preproprotein

      See identical proteins and their annotated locations for NP_058767.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8J8Y5N6, A0A9K3Y780, F1LN53, F1LPL6, T2CB11
      Related
      ENSRNOP00000060141.4, ENSRNOT00000067448.5
      Conserved Domains (6) summary
      cd05061
      Location:10181305
      PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
      cd00063
      Location:869946
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00064
      Location:234281
      FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
      pfam00757
      Location:179337
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:359472
      Recep_L_domain; Receptor L domain
      pfam07714
      Location:10251292
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      5991135..6129275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271068.1XP_063127138.1  insulin receptor isoform X3

      UniProtKB/TrEMBL
      A0A8J8Y5N6
    2. XM_039089097.2XP_038945025.1  insulin receptor isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZMZ8, A0A8J8Y5N6
      Conserved Domains (5) summary
      cd05061
      Location:10061293
      PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
      cd00063
      Location:857934
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:179337
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:359472
      Recep_L_domain; Receptor L domain
      pfam17870
      Location:930977
      Insulin_TMD; Insulin receptor trans-membrane segment
    3. XM_039089096.2XP_038945024.1  insulin receptor isoform X1

      UniProtKB/TrEMBL
      A0A8J8Y5N6
      Conserved Domains (5) summary
      cd05061
      Location:10171304
      PTKc_InsR; Catalytic domain of the Protein Tyrosine Kinase, Insulin Receptor
      cd00063
      Location:869946
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00757
      Location:179337
      Furin-like; Furin-like cysteine rich region
      pfam01030
      Location:359472
      Recep_L_domain; Receptor L domain
      pfam17870
      Location:942988
      Insulin_TMD; Insulin receptor trans-membrane segment
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