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    Psrc1 proline and serine rich coiled-coil 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 691380, updated on 9-Dec-2024

    Summary

    Official Symbol
    Psrc1provided by RGD
    Official Full Name
    proline and serine rich coiled-coil 1provided by RGD
    Primary source
    RGD:1585037
    See related
    EnsemblRapid:ENSRNOG00000020013 AllianceGenome:RGD:1585037
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including mitotic metaphase chromosome alignment; positive regulation of macromolecule metabolic process; and regulation of microtubule cytoskeleton organization. Predicted to be located in several cellular components, including midbody; nucleoplasm; and spindle. Predicted to be active in microtubule cytoskeleton. Predicted to colocalize with spindle microtubule and spindle pole. Orthologous to human PSRC1 (proline and serine rich coiled-coil 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 21.3), Thymus (RPKM 12.2) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Psrc1 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198710427..198715001)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (196022361..196026874)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (211176437..211181078)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene sortilin 1 Neighboring gene uncharacterized LOC134485672 Neighboring gene myosin binding protein H-like Neighboring gene cadherin, EGF LAG seven-pass G-type receptor 2 Neighboring gene uncharacterized LOC108350091 Neighboring gene seryl-tRNA synthetase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Clone Names

    • MGC125042

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables microtubule binding  
    enables microtubule binding  
    enables microtubule binding  
    Process Evidence Code Pubs
    involved_in cell division  
    involved_in microtubule bundle formation  
    involved_in microtubule bundle formation  
    involved_in mitotic metaphase chromosome alignment  
    involved_in mitotic metaphase chromosome alignment  
    involved_in mitotic metaphase chromosome alignment  
    involved_in mitotic metaphase chromosome alignment  
    involved_in negative regulation of cell growth  
    involved_in negative regulation of cell growth  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity  
    involved_in positive regulation of microtubule polymerization  
    involved_in positive regulation of microtubule polymerization  
    involved_in regulation of mitotic spindle organization  
    involved_in regulation of mitotic spindle organization  
    involved_in regulation of mitotic spindle organization  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    is_active_in microtubule cytoskeleton  
    located_in microtubule cytoskeleton  
    located_in midbody  
    located_in midbody  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in spindle  
    colocalizes_with spindle microtubule  
    located_in spindle microtubule  
    located_in spindle microtubule  
    located_in spindle microtubule  
    colocalizes_with spindle pole  
    located_in spindle pole  
    located_in spindle pole  
    located_in spindle pole  

    General protein information

    Preferred Names
    proline/serine-rich coiled-coil protein 1
    Names
    proline/serine-rich coiled-coil 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001044302.1NP_001037767.1  proline/serine-rich coiled-coil protein 1

      See identical proteins and their annotated locations for NP_001037767.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105874
      UniProtKB/Swiss-Prot
      Q3KR66
      UniProtKB/TrEMBL
      A0A8I6ASD1, A6HV00
      Related
      ENSRNOP00000052733.1, ENSRNOT00000055880.4
      Conserved Domains (1) summary
      pfam15259
      Location:10124
      GTSE1_N; G-2 and S-phase expressed 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      198710427..198715001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282592.1XP_063138662.1  proline/serine-rich coiled-coil protein 1 isoform X3

      UniProtKB/Swiss-Prot
      Q3KR66
      UniProtKB/TrEMBL
      A0A8I6ASD1, A6HV00
    2. XM_006233179.4XP_006233241.1  proline/serine-rich coiled-coil protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006233241.1

      UniProtKB/Swiss-Prot
      Q3KR66
      UniProtKB/TrEMBL
      A0A8I6ASD1, A6HV00
      Conserved Domains (1) summary
      pfam15259
      Location:10124
      GTSE1_N; G-2 and S-phase expressed 1
    3. XM_006233176.5XP_006233238.1  proline/serine-rich coiled-coil protein 1 isoform X2

      See identical proteins and their annotated locations for XP_006233238.1

      UniProtKB/Swiss-Prot
      Q3KR66
      UniProtKB/TrEMBL
      A0A8I6ASD1, A6HV00
      Conserved Domains (1) summary
      pfam15259
      Location:10124
      GTSE1_N; G-2 and S-phase expressed 1
    4. XM_006233177.4XP_006233239.2  proline/serine-rich coiled-coil protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASD1
      Related
      ENSRNOP00000111385.1, ENSRNOT00000161076.1
      Conserved Domains (2) summary
      pfam05109
      Location:182348
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam15259
      Location:61175
      GTSE1_N; G-2 and S-phase expressed 1
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