Rab17 RAB17, member RAS oncogene family [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rab17provided by RGD
Official Full Name: RAB17, member RAS oncogene familyprovided by RGD
Primary source: RGD:1562478
See related: EnsemblRapid:ENSRNOG00000052979 AllianceGenome:RGD:1562478
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1562478
Summary: Predicted to enable GDP binding activity and GTPase activity. Predicted to be involved in several processes, including immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; plasma membrane bounded cell projection assembly; and regulation of plasma membrane bounded cell projection organization. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic vesicle. Predicted to be active in several cellular components, including endosome; glutamatergic synapse; and postsynapse. Orthologous to human RAB17 (RAB17, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 321.9), Liver (RPKM 163.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 9q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (99001044..99014340, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (91552924..91566759, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (98118907..98131883, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors determined that transcytosis of three classes of newly synthesized apical residents showed similar responses to rab17 mutant expression, indicating that rab17 is a general component of the transcytotic machinery required for apically destined vesicle docking and fusion.
Title: Rab17 regulates apical delivery of hepatic transcytotic vesicles.
These data suggest that Rab17 mediates the dendritic trafficking of Syntaxin-4 to selectively regulate dendritic surface insertion of GluK2-containing KARs in rat hippocampal neurons.
Title: Small GTPase Rab17 regulates the surface expression of kainate receptors but not α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in hippocampal neurons via dendritic trafficking of Syntaxin-4 protein.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde dendritic transport	ISO Inferred from Sequence Orthology more info
involved_in cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocytic recycling	ISO Inferred from Sequence Orthology more info
NOT involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in establishment of melanosome localization	ISO Inferred from Sequence Orthology more info
involved_in filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	ISO Inferred from Sequence Orthology more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanosome transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendrite development	ISO Inferred from Sequence Orthology more info
involved_in regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in transcytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
NOT located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
is_active_in recycling endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ras-related protein Rab-17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109363.2 → NP_001102833.1 ras-related protein Rab-17

See identical proteins and their annotated locations for NP_001102833.1

Status: PROVISIONAL

Source sequence(s)

BC167022

UniProtKB/TrEMBL

A0A0G2JTD9, A0A9K3Y7P9, B2RZ46

Related

ENSRNOP00000068669.2, ENSRNOT00000079446.3

Conserved Domains (1) summary

cd01860
Location:21 → 181

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

99001044..99014340 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039084134.2 → XP_038940062.1 ras-related protein Rab-17 isoform X1

UniProtKB/TrEMBL

A0A0G2JTD9, A0A9K3Y7P9, B2RZ46

Conserved Domains (1) summary

cd01860
Location:21 → 181

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion
XM_039084135.2 → XP_038940063.1 ras-related protein Rab-17 isoform X1

UniProtKB/TrEMBL

A0A0G2JTD9, A0A9K3Y7P9, B2RZ46

Conserved Domains (1) summary

cd01860
Location:21 → 181

Rab5_related; Rab-related GTPase family includes Rab5 and Rab22; regulates early endosome fusion