U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Cntnap2 contactin associated protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500105, updated on 27-Dec-2024

    Summary

    Official Symbol
    Cntnap2provided by RGD
    Official Full Name
    contactin associated protein 2provided by RGD
    Primary source
    RGD:1307076
    See related
    EnsemblRapid:ENSRNOG00000006617 AllianceGenome:RGD:1307076
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protease binding activity and transmembrane transporter binding activity. Involved in prepulse inhibition. Located in several cellular components, including main axon; neuronal cell body; and synaptic membrane. Is active in GABA-ergic synapse; glutamatergic synapse; and presynaptic membrane. Used to study autism spectrum disorder and epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autism spectrum disorder (multiple); communication disorder (multiple); cortical dysplasia-focal epilepsy syndrome; major depressive disorder; and social phobia. Orthologous to human CNTNAP2 (contactin associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 151.1), Testes (RPKM 25.1) and 3 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cntnap2 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (75109358..77366258)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (74109455..76366434)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (74700539..77025463)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102161 Neighboring gene ST13, Hsp70 interacting protein, pseudogene 9 Neighboring gene transfer RNA valine (anticodon AAC) 34 Neighboring gene uncharacterized LOC102549191 Neighboring gene uncharacterized LOC103692120 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC102549132 Neighboring gene uncharacterized LOC134486576 Neighboring gene small nuclear ribonucleoprotein polypeptides B and B1, pseudogene 2 Neighboring gene cullin 1 Neighboring gene enhancer of zeste 2 polycomb repressive complex 2 subunit

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding  
    enables enzyme binding  
    enables protease binding PubMed 
    enables transmembrane transporter binding PubMed 
    Items 1 - 25 of 82
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade  
    involved_in TOR signaling  
    involved_in action potential initiation  
    involved_in adult behavior  
    involved_in associative learning  
    involved_in axonogenesis  
    involved_in behavioral response to pain  
    involved_in cell adhesion  
    involved_in cell morphogenesis  
    involved_in cell population proliferation  
    involved_in central nervous system myelination  
    involved_in cerebellar Purkinje cell layer morphogenesis  
    involved_in cerebellum development  
    involved_in cerebral cortex development  
    involved_in chemical synaptic transmission  
    involved_in circadian sleep/wake cycle  
    involved_in clustering of voltage-gated potassium channels  
    involved_in dendrite arborization  
    involved_in dendritic spine development  
    involved_in dendritic spine maintenance  
    involved_in dendritic spine organization  
    involved_in embryonic brain development  
    involved_in excitatory chemical synaptic transmission  
    involved_in excitatory postsynaptic potential  
    involved_in excitatory synapse assembly  
    involved_in fat cell differentiation  
    involved_in gene expression  
    involved_in glial cell proliferation  
    acts_upstream_of_or_within glutamatergic neuron differentiation  
    involved_in grooming behavior  
    involved_in in utero embryonic development  
    involved_in inflammatory response  
    involved_in inhibitory chemical synaptic transmission  
    involved_in inhibitory synapse assembly  
    involved_in intracellular signal transduction  
    involved_in learning  
    involved_in limbic system development  
    involved_in locomotor rhythm  
    involved_in locomotory behavior  
    involved_in maintenance of synapse structure  
    involved_in mitochondrion organization  
    involved_in motor behavior  
    involved_in multicellular organism growth  
    involved_in myelination  
    involved_in negative regulation of neuronal action potential  
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in negative regulation of synaptic transmission, GABAergic  
    involved_in neural precursor cell proliferation  
    involved_in neuromuscular junction development, skeletal muscle fiber  
    involved_in neuromuscular process  
    involved_in neuromuscular process controlling posture  
    acts_upstream_of_or_within neuron projection development  
    involved_in neuron projection morphogenesis  
    involved_in neuronal action potential  
    involved_in positive regulation of gap junction assembly  
    involved_in positive regulation of neuronal action potential  
    involved_in postsynaptic density organization  
    involved_in prepulse inhibition PubMed 
    involved_in protein localization  
    acts_upstream_of_or_within protein localization to juxtaparanode region of axon  
    involved_in protein localization to juxtaparanode region of axon  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels  
    involved_in response to dietary excess  
    involved_in response to heat  
    involved_in response to hormone  
    involved_in response to interleukin-17  
    involved_in response to light intensity  
    involved_in response to mechanical stimulus  
    involved_in response to metformin  
    involved_in response to odorant  
    involved_in response to pain  
    involved_in response to xenobiotic stimulus  
    involved_in rhythmic behavior  
    involved_in social behavior  
    involved_in startle response PubMed 
    involved_in striatum development  
    involved_in superior temporal gyrus development  
    involved_in thalamus development  
    involved_in transmission of nerve impulse  
    involved_in vocal learning  
    involved_in vocalization behavior  
    involved_in walking behavior  
    Items 1 - 25 of 82
    Items 1 - 20 of 32
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    located_in Golgi apparatus  
    located_in axolemma PubMed 
    located_in axolemma  
    located_in axon  
    is_active_in axon initial segment  
    located_in cell surface  
    is_active_in cerebellar granule cell to Purkinje cell synapse  
    located_in dendrite PubMed 
    is_active_in dendrite  
    located_in early endosome  
    is_active_in excitatory synapse  
    located_in excitatory synapse  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in juxtaparanode region of axon PubMed 
    located_in juxtaparanode region of axon  
    located_in membrane  
    is_active_in neuron projection  
    is_active_in neuron spine  
    located_in neuronal cell body PubMed 
    is_active_in neuronal cell body  
    located_in paranodal junction  
    located_in paranode region of axon PubMed 
    is_active_in plasma membrane raft  
    is_active_in postsynapse  
    is_active_in presynapse  
    is_active_in presynaptic active zone membrane  
    is_active_in presynaptic membrane PubMed 
    is_active_in synapse  
    located_in synaptic membrane PubMed 
    part_of voltage-gated potassium channel complex  
    Items 1 - 20 of 32

    General protein information

    Preferred Names
    contactin-associated protein-like 2
    Names
    contactin associated protein-like 2
    mKIAA0868 protein-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427648.1NP_001414577.1  contactin-associated protein-like 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6GH02
      Related
      ENSRNOP00000088343.1, ENSRNOT00000008688.9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      75109358..77366258
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109027.2XP_038964955.1  contactin-associated protein-like 2 isoform X1

      Conserved Domains (6) summary
      smart00294
      Location:779797
      4.1m; putative band 4.1 homologues' binding motif
      cd00054
      Location:5186
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:296439
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:463488
      EGF; EGF-like domain
      pfam02210
      Location:552684
      Laminin_G_2; Laminin G domain
      cl02436
      Location:105128
      COLFI; Fibrillar collagen C-terminal domain
    2. XM_039109028.2XP_038964956.1  contactin-associated protein-like 2 isoform X1

      Conserved Domains (6) summary
      smart00294
      Location:779797
      4.1m; putative band 4.1 homologues' binding motif
      cd00054
      Location:5186
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00110
      Location:296439
      LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
      pfam00008
      Location:463488
      EGF; EGF-like domain
      pfam02210
      Location:552684
      Laminin_G_2; Laminin G domain
      cl02436
      Location:105128
      COLFI; Fibrillar collagen C-terminal domain
    External link. Please review our privacy policy.