Arrdc3 arrestin domain containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Arrdc3provided by RGD
Full Name: arrestin domain containing 3provided by RGD
Primary source: RGD:1359478
See related: EnsemblRapid:ENSRNOG00000045649 AllianceGenome:RGD:1359478
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: LRRGT00048
Summary: Predicted to enable beta-3 adrenergic receptor binding activity. Predicted to be involved in negative regulation of cold-induced thermogenesis; positive regulation of hippo signaling; and protein transport. Predicted to act upstream of or within several processes, including fat pad development; negative regulation of locomotion involved in locomotory behavior; and positive regulation of ubiquitin-protein transferase activity. Predicted to be located in early endosome and lysosome. Predicted to be active in endosome and plasma membrane. Orthologous to human ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 774.4), Adrenal (RPKM 559.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (12873202..12885716)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (11137464..11149978)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (8732907..8745445)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ARRDC3 inhibits liver fibrosis and epithelial-to-mesenchymal transition via the ITGB4/PI3K/Akt signaling pathway.
Title: ARRDC3 inhibits liver fibrosis and epithelial-to-mesenchymal transition via the ITGB4/PI3K/Akt signaling pathway.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-3 adrenergic receptor binding	IEA Inferred from Electronic Annotation more info
enables beta-3 adrenergic receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fat pad development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fat pad development	ISO Inferred from Sequence Orthology more info
involved_in heat generation	IEA Inferred from Electronic Annotation more info
acts_upstream_of heat generation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cold-induced thermogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of heat generation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of heat generation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of locomotion involved in locomotory behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of locomotion involved in locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in skin development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within temperature homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arrestin domain-containing protein 3

Names: liver regeneration-related protein LRRG00048

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007797.2 → NP_001007798.1 arrestin domain-containing protein 3

See identical proteins and their annotated locations for NP_001007798.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

Q6TXF1

UniProtKB/TrEMBL

A0A8L2QZ95, A6I4I1

Related

ENSRNOP00000078331.1, ENSRNOT00000106948.2

Conserved Domains (2) summary

smart01017
Location:187 → 314

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:22 → 165

Arrestin_N; Arrestin (or S-antigen), N-terminal domain