Kmt2b lysine methyltransferase 2B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kmt2bprovided by RGD
Official Full Name: lysine methyltransferase 2Bprovided by RGD
Primary source: RGD:7678027
See related: EnsemblRapid:ENSRNOG00000055525 AllianceGenome:RGD:7678027
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mll4; Wbp7; RGD1308331
Summary: Predicted to enable histone H3K4 methyltransferase activity; unmethylated CpG binding activity; and zinc ion binding activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to act upstream of or within several processes, including ovarian follicle development; ovulation; and regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of MLL1/2 complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; colorectal adenocarcinoma; dystonia 28, childhood-onset; and hepatocellular carcinoma. Orthologous to human KMT2B (lysine methyltransferase 2B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 51.0), Spleen (RPKM 46.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (94949144..94969239, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (85821700..85840987, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (89022889..89042176, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Histone methyltransferase MLL4 protects against pressure overload-induced heart failure via a THBS4-mediated protection in ER stress.
Title: Histone methyltransferase MLL4 protects against pressure overload-induced heart failure via a THBS4-mediated protection in ER stress.
KMT2B-dependent RFK transcription activates the TNF-alpha/NOX2 pathway and enhances ferroptosis caused by myocardial ischemia-reperfusion.
Title: KMT2B-dependent RFK transcription activates the TNF-α/NOX2 pathway and enhances ferroptosis caused by myocardial ischemia-reperfusion.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone H3K4 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H3K4 methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables histone H3K4 trimethyltransferase activity	IEA Inferred from Electronic Annotation more info
enables unmethylated CpG binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA methylation-dependent constitutive heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within maternal-to-zygotic transition of gene expression	ISO Inferred from Sequence Orthology more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oocyte development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ovarian follicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ovulation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MLL1/2 complex	ISO Inferred from Sequence Orthology more info
part_of histone methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of histone methyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase 2B

Names: WW domain binding protein 7; histone-lysine N-methyltransferase 2B-like; lysine (K)-specific methyltransferase 2B; myeloid/lymphoid or mixed-lineage leukemia 4

NP_001414070.1

EC 2.1.1.354

EC 2.1.1.364

XP_008757476.1

EC 2.1.1.354

EC 2.1.1.364

XP_038949806.1

EC 2.1.1.354

EC 2.1.1.364

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427141.1 → NP_001414070.1 histone-lysine N-methyltransferase 2B

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A0G2K1E3, A0A8I6G8S5

Related

ENSRNOP00000071806.1, ENSRNOT00000080842.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

94949144..94969239 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008759254.4 → XP_008757476.1 histone-lysine N-methyltransferase 2B isoform X1

UniProtKB/TrEMBL

A0A8I6G8S5

Conserved Domains (10) summary

cd05493
Location:1373 → 1515

Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...

smart00542
Location:2411 → 2495

FYRC; FY-rich domain, C-terminal region

smart00317
Location:2575 → 2695

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG2940
Location:2557 → 2713

SET; SET domain-containing protein (function unknown) [General function prediction only]

pfam02008
Location:956 → 1003

zf-CXXC; CXXC zinc finger domain

cd15589
Location:1202 → 1248

PHD1_KMT2B; PHD finger 1 found in Histone-lysine N-methyltransferase 2B (KMT2B)

cd15591
Location:1250 → 1299

PHD2_KMT2B; PHD domain 2 found in Histone-lysine N-methyltransferase 2B (KMT2B)

cd15593
Location:1336 → 1392

PHD3_KMT2B; PHD finger 3 found in Histone-lysine N-methyltransferase 2B (KMT2B)

cd15694
Location:1580 → 1684

ePHD_KMT2B; Extended PHD finger found in histone-lysine N-methyltransferase 2B (KMT2B)

pfam05964
Location:1733 → 1779

FYRN; F/Y-rich N-terminus
XM_039093878.2 → XP_038949806.1 histone-lysine N-methyltransferase 2B isoform X2

Conserved Domains (9) summary

cd05493
Location:363 → 505

Bromo_ALL-1; Bromodomain, ALL-1 like proteins. ALL-1 is a vertebrate homologue of Drosophila trithorax and is often affected in chromosomal rearrangements that are linked to acute leukemias, such as acute lymphocytic leukemia (ALL). Bromodomains are found in many ...

smart00542
Location:1402 → 1486

FYRC; FY-rich domain, C-terminal region

PHA03247
Location:781 → 1355

PHA03247; large tegument protein UL36; Provisional

cd15589
Location:192 → 238

PHD1_KMT2B; PHD finger 1 found in Histone-lysine N-methyltransferase 2B (KMT2B)

cd15591
Location:240 → 289

PHD2_KMT2B; PHD domain 2 found in Histone-lysine N-methyltransferase 2B (KMT2B)

cd15593
Location:326 → 382

PHD3_KMT2B; PHD finger 3 found in Histone-lysine N-methyltransferase 2B (KMT2B)

cd15694
Location:570 → 674

ePHD_KMT2B; Extended PHD finger found in histone-lysine N-methyltransferase 2B (KMT2B)

cd19170
Location:1551 → 1704

SET_KMT2A_2B; SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins

pfam05964
Location:722 → 769

FYRN; F/Y-rich N-terminus