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    Calr4 calreticulin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689537, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Calr4provided by RGD
    Official Full Name
    calreticulin 4provided by RGD
    Primary source
    RGD:1591090
    See related
    EnsemblRapid:ENSRNOG00000037710 AllianceGenome:RGD:1591090
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in ERAD pathway and protein folding. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 9.0), Testes (RPKM 5.7) and 6 other tissues See more
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    Genomic context

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    See Calr4 in Genome Data Viewer
    Location:
    5q34
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (129216293..129251077)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (123986870..124022436)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (128865339..128900135)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene oxysterol binding protein-like 9 Neighboring gene uncharacterized LOC120103121 Neighboring gene uncharacterized LOC134486963 Neighboring gene uncharacterized LOC108351012 Neighboring gene epidermal growth factor receptor pathway substrate 15 Neighboring gene tetratricopeptide repeat domain 39A Neighboring gene ring finger protein 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    calreticulin 4; calreticulin
    Names
    rCG50286-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431272.1 → NP_001418201.1  calreticulin 4 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JYX7, D3ZYM6

    2. NM_001431273.1 → NP_001418202.1  calreticulin 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      F1M5A1

    3. NM_001431274.1 → NP_001418203.1  calreticulin 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    4. NM_001431275.1 → NP_001418204.1  calreticulin 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    5. NM_001431276.1 → NP_001418205.1  calreticulin 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      129216293..129251077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111174.2 → XP_038967102.1  calreticulin isoform X6

      Related
      ENSRNOP00000063135.4, ENSRNOT00000068697.6
      Conserved Domains (2) summary
      PRK00409
      Location:342 → 390
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      pfam00262
      Location:28 → 337
      Calreticulin; Calreticulin family

    2. XM_039111171.2 → XP_038967099.1  calreticulin isoform X2

      UniProtKB/TrEMBL
      F1M5A1
      Related
      ENSRNOP00000108568.1, ENSRNOT00000135990.1
      Conserved Domains (2) summary
      PRK00409
      Location:313 → 361
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      pfam00262
      Location:7 → 308
      Calreticulin; Calreticulin family

    3. XM_063288593.1 → XP_063144663.1  calreticulin isoform X5

    4. XM_039111172.2 → XP_038967100.1  calreticulin isoform X3

      Conserved Domains (2) summary
      PRK00409
      Location:277 → 325
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      pfam00262
      Location:41 → 272
      Calreticulin; Calreticulin family

    5. XM_039111170.2 → XP_038967098.1  calreticulin isoform X1

      Related
      ENSRNOP00000105072.1, ENSRNOT00000159576.1
      Conserved Domains (2) summary
      PRK00409
      Location:347 → 395
      PRK00409; recombination and DNA strand exchange inhibitor protein; Reviewed
      pfam00262
      Location:41 → 342
      Calreticulin; Calreticulin family

    6. XM_063288592.1 → XP_063144662.1  calreticulin isoform X4

      UniProtKB/TrEMBL
      A6JYX8
    Nucleotide Protein Strain
    Heading Accession and Version

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