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    Timp1 TIMP metallopeptidase inhibitor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116510, updated on 4-Jan-2025

    Summary

    Official Symbol
    Timp1provided by RGD
    Official Full Name
    TIMP metallopeptidase inhibitor 1provided by RGD
    Primary source
    RGD:621675
    See related
    EnsemblRapid:ENSRNOG00000010208 AllianceGenome:RGD:621675
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Timp; TIMP-1
    Summary
    Enables protease binding activity. Involved in several processes, including cartilage development; cellular response to peptide; and response to peptide hormone. Located in basement membrane. Used to study degenerative disc disease. Biomarker of several diseases, including gastric ulcer; heart disease (multiple); lung disease (multiple); metabolic dysfunction-associated steatohepatitis; and vascular disease (multiple). Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 146.9), Uterus (RPKM 130.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Timp1 in Genome Data Viewer
    Location:
    Xq11
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (3766509..3772578, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (1212969..1217714, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (1364771..1369451, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene complement factor properdin Neighboring gene synapsin I Neighboring gene 60S ribosomal protein L12-like Neighboring gene A-Raf proto-oncogene, serine/threonine kinase Neighboring gene uncharacterized LOC134484040 Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene ribosomal protein L22 like 1, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity  
    enables cytokine activity  
    enables growth factor activity  
    enables metalloendopeptidase inhibitor activity  
    enables metalloendopeptidase inhibitor activity  
    enables metalloendopeptidase inhibitor activity  
    enables metalloendopeptidase inhibitor activity PubMed 
    enables peptidase inhibitor activity  
    enables protease binding PubMed 
    enables protein binding PubMed 
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in cartilage development PubMed 
    involved_in cellular response to UV-A  
    involved_in cellular response to UV-A  
    involved_in cellular response to peptide PubMed 
    acts_upstream_of_or_within connective tissue replacement involved in inflammatory response wound healing  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of catalytic activity  
    involved_in negative regulation of catalytic activity  
    involved_in negative regulation of endopeptidase activity  
    involved_in negative regulation of endopeptidase activity  
    involved_in negative regulation of membrane protein ectodomain proteolysis  
    involved_in negative regulation of membrane protein ectodomain proteolysis  
    involved_in negative regulation of metallopeptidase activity  
    involved_in negative regulation of trophoblast cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in regulation of integrin-mediated signaling pathway  
    involved_in regulation of integrin-mediated signaling pathway  
    involved_in response to cytokine  
    involved_in response to cytokine PubMed 
    involved_in response to hormone  
    involved_in response to peptide hormone PubMed 
    involved_in signal transduction  
    involved_in steroid biosynthetic process  
    Component Evidence Code Pubs
    located_in basement membrane PubMed 
    located_in basement membrane  
    is_active_in extracellular matrix  
    located_in extracellular matrix  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    metalloproteinase inhibitor 1
    Names
    tissue inhibitor of metallopeptidase 1
    tissue inhibitor of metalloproteinase 1
    tissue inhibitor of metalloproteinases 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053819.1NP_446271.1  metalloproteinase inhibitor 1 precursor

      See identical proteins and their annotated locations for NP_446271.1

      Status: PROVISIONAL

      Source sequence(s)
      L31883
      UniProtKB/Swiss-Prot
      P30120, P70533, Q53YM7
      UniProtKB/TrEMBL
      A6JZR1
      Related
      ENSRNOP00000013745.4, ENSRNOT00000013745.9
      Conserved Domains (1) summary
      smart00206
      Location:24199
      NTR; Tissue inhibitor of metalloproteinase family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      3766509..3772578 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256608.4XP_006256670.1  metalloproteinase inhibitor 1 isoform X1

      See identical proteins and their annotated locations for XP_006256670.1

      UniProtKB/Swiss-Prot
      P30120, P70533, Q53YM7
      UniProtKB/TrEMBL
      A6JZR1
      Conserved Domains (1) summary
      smart00206
      Location:24199
      NTR; Tissue inhibitor of metalloproteinase family
    2. XM_039099406.2XP_038955334.1  metalloproteinase inhibitor 1 isoform X1

      UniProtKB/Swiss-Prot
      P30120, P70533, Q53YM7
      UniProtKB/TrEMBL
      A6JZR1
      Conserved Domains (1) summary
      smart00206
      Location:24199
      NTR; Tissue inhibitor of metalloproteinase family
    3. XM_039099407.2XP_038955335.1  metalloproteinase inhibitor 1 isoform X1

      UniProtKB/Swiss-Prot
      P30120, P70533, Q53YM7
      UniProtKB/TrEMBL
      A6JZR1
      Conserved Domains (1) summary
      smart00206
      Location:24199
      NTR; Tissue inhibitor of metalloproteinase family
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