Nup58 nucleoporin 58 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nup58provided by RGD
Official Full Name: nucleoporin 58provided by RGD
Primary source: RGD:631334
See related: EnsemblRapid:ENSRNOG00000012644 AllianceGenome:RGD:631334
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nup45; Nupl1; p58/p45
Summary: Enables identical protein binding activity and nuclear localization sequence binding activity. A structural constituent of nuclear pore. Involved in nucleocytoplasmic transport and regulation of protein import into nucleus. Located in nuclear envelope. Part of nuclear pore. Orthologous to human NUP58 (nucleoporin 58). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 123.7), Spleen (RPKM 106.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (38534340..38583959, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (34358170..34407160, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (40496754..40545933, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we carried out solution analysis utilizing the entire ordered regions of Nup62, Nup54, and Nup58, and demonstrate that they form a dynamic "triple complex"
Title: Ordered Regions of Channel Nucleoporins Nup62, Nup54, and Nup58 Form Dynamic Complexes in Solution.
A 1:1:1 stoichiometry of the Nup62 complex, where Nup54 is central with direct binding to Nup62 and Nup58.
Title: The stoichiometry of the nucleoporin 62 subcomplex of the nuclear pore in solution.
Study reports the crystal structures of the Nup54-Nup58 and Nup62-Nup54 interacting domains and reconstruct the molecular architecture of the NPC transport channel.
Title: Molecular architecture of the transport channel of the nuclear pore complex.
crystal structure of alpha-helical region of Nup58/45; we identified distinct tetramers, each consisting of two antiparallel hairpin dimers [Nup58, Nup45]
Title: Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular sliding.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131539 (e-PCR)
- UniSTS:214822

RH144130 (e-PCR)
- UniSTS:233376

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear localization sequence binding	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear localization sequence binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear localization sequence binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nucleocytoplasmic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nucleoporin p58/p45

Names: 58 kDa nucleoporin; nucleoporin p45; nucleoporin p58; nucleoporin-like 1; nucleoporin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_139091.2 → NP_620791.1 nucleoporin p58/p45

See identical proteins and their annotated locations for NP_620791.1

Status: PROVISIONAL

Source sequence(s)

BC085690

UniProtKB/Swiss-Prot

P70581, Q9JHE1, Q9QWK7, Q9Z2W7

UniProtKB/TrEMBL

A0A8I6G353, A6K694, A6K695

Related

ENSRNOP00000084647.1, ENSRNOT00000095956.2

Conserved Domains (2) summary

pfam10154
Location:230 → 408

DUF2362; Uncharacterized conserved protein (DUF2362)

pfam15967
Location:32 → 585

Nucleoporin_FG2; Nucleoporin FG repeated region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

38534340..38583959 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092982.2 → XP_038948910.1 nucleoporin p58/p45 isoform X3

UniProtKB/TrEMBL

A6K694

Conserved Domains (1) summary

pfam15967
Location:2 → 522

Nucleoporin_FG2; Nucleoporin FG repeated region
XM_006252093.5 → XP_006252155.1 nucleoporin p58/p45 isoform X2

See identical proteins and their annotated locations for XP_006252155.1

UniProtKB/TrEMBL

A0A8L2Q9I5, A6K693, A6K694

Related

ENSRNOP00000017204.6, ENSRNOT00000017204.9

Conserved Domains (1) summary

pfam15967
Location:32 → 539

Nucleoporin_FG2; Nucleoporin FG repeated region
XM_039092981.2 → XP_038948909.1 nucleoporin p58/p45 isoform X1

UniProtKB/TrEMBL

A6K694

Related

ENSRNOP00000078538.1, ENSRNOT00000101273.2

Conserved Domains (1) summary

pfam15967
Location:2 → 568

Nucleoporin_FG2; Nucleoporin FG repeated region