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    Arpc4 actin related protein 2/3 complex, subunit 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297518, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arpc4provided by RGD
    Official Full Name
    actin related protein 2/3 complex, subunit 4provided by RGD
    Primary source
    RGD:1310096
    See related
    EnsemblRapid:ENSRNOG00000008994 AllianceGenome:RGD:1310096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity and enzyme binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to contribute to protein-macromolecule adaptor activity. Predicted to be involved in Arp2/3 complex-mediated actin nucleation. Predicted to be located in cell projection and cytoplasm. Predicted to be part of Arp2/3 protein complex. Orthologous to human ARPC4 (actin related protein 2/3 complex subunit 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 686.3), Thymus (RPKM 577.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Arpc4 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (148077799..148088427)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (146522255..146532784)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145330457..145340985)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene gamma-glutamylamine cyclotransferase, pseudogene 2 Neighboring gene U2 spliceosomal RNA Neighboring gene transcriptional adaptor 3 Neighboring gene tubulin tyrosine ligase like 3 Neighboring gene RNA pseudouridine synthase D3 Neighboring gene uncharacterized LOC102548450

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of Arp2/3 protein complex  
    located_in cytoplasm  

    General protein information

    Preferred Names
    actin-related protein 2/3 complex subunit 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106615.2NP_001100085.2  actin-related protein 2/3 complex subunit 4

      See identical proteins and their annotated locations for NP_001100085.2

      Status: VALIDATED

      Source sequence(s)
      BC167049, BQ781452, CK478610
      UniProtKB/TrEMBL
      A0A8I6ALX8, A6IBR0, B2RZ72, F7FBT6
      Related
      ENSRNOP00000076936.2, ENSRNOT00000113206.2
      Conserved Domains (1) summary
      pfam05856
      Location:1166
      ARPC4; ARP2/3 complex 20 kDa subunit (ARPC4)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      148077799..148088427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285880.1XP_063141950.1  actin-related protein 2/3 complex subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ALX8
      Related
      ENSRNOP00000104675.1, ENSRNOT00000129200.1
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