Lrrc39 leucine rich repeat containing 39 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lrrc39provided by RGD
Official Full Name: leucine rich repeat containing 39provided by RGD
Primary source: RGD:1585106
See related: EnsemblRapid:ENSRNOG00000015117 AllianceGenome:RGD:1585106
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in intracellular signal transduction. Predicted to be located in M band. Orthologous to human LRRC39 (leucine rich repeat containing 39). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 614.5), Muscle (RPKM 310.6) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (207201039..207220375)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (204516122..204535463)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (219598162..219617498)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reveal myomasp/LRRC39 as a previously unrecognized component of an M-band-associated signaling pathway that regulates cardiomyocyte gene expression in response to biomechanical stress.
Title: Myomasp/LRRC39, a heart- and muscle-specific protein, is a novel component of the sarcomeric M-band and is involved in stretch sensing.

Submit: New GeneRIF Correction

General gene information

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Markers

BI295662 (e-PCR)
- UniSTS:246680

RH141435 (e-PCR)
- UniSTS:223429

NoName (e-PCR)
- UniSTS:487624

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in M band	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: leucine-rich repeat-containing protein 39

Names: myomasp; myosin-interacting M-band-associated stress-responsive protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109637.1 → NP_001103107.1 leucine-rich repeat-containing protein 39

See identical proteins and their annotated locations for NP_001103107.1

Status: PROVISIONAL

Source sequence(s)

CH473952

UniProtKB/Swiss-Prot

D3ZXS4

Related

ENSRNOP00000020297.5, ENSRNOT00000020297.7

Conserved Domains (2) summary

COG4886
Location:41 → 286

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:85 → 107

LRR_RI; leucine-rich repeat [structural motif]