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    Tsen54 tRNA splicing endonuclease subunit 54 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690308, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tsen54provided by RGD
    Official Full Name
    tRNA splicing endonuclease subunit 54provided by RGD
    Primary source
    RGD:1597379
    See related
    EnsemblRapid:ENSRNOG00000004598 AllianceGenome:RGD:1597379
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in tRNA-type intron splice site recognition and cleavage. Predicted to be part of tRNA-intron endonuclease complex. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 2A; pontocerebellar hypoplasia type 4; and pontocerebellar hypoplasia type 5. Orthologous to human TSEN54 (tRNA splicing endonuclease subunit 54). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 26.8), Muscle (RPKM 26.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Tsen54 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (101540479..101549022)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (101041607..101050088)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (104358401..104366926)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 94 Neighboring gene microRNA 3577 Neighboring gene cask-interacting protein 2 Neighboring gene LLGL scribble cell polarity complex component 2 Neighboring gene myosin XVB

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of tRNA-intron endonuclease complex  

    General protein information

    Preferred Names
    tRNA-splicing endonuclease subunit Sen54
    Names
    TSEN54 tRNA splicing endonuclease subunit
    tRNA splicing endonuclease 54 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109576.1NP_001103046.1  tRNA-splicing endonuclease subunit Sen54

      See identical proteins and their annotated locations for NP_001103046.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473948
      UniProtKB/TrEMBL
      A0A8I6AEJ0, A6HKQ9, D3ZZT6
      Conserved Domains (1) summary
      pfam12928
      Location:63130
      tRNA_int_end_N2; tRNA-splicing endonuclease subunit sen54 N-term

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      101540479..101549022
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039086874.2XP_038942802.1  tRNA-splicing endonuclease subunit Sen54 isoform X1

      Conserved Domains (2) summary
      pfam12928
      Location:67134
      tRNA_int_end_N2; tRNA-splicing endonuclease subunit sen54 N-term
      cl40623
      Location:120191
      tRNA_int_end_N2; tRNA-splicing endonuclease subunit sen54 N-term
    2. XM_039086876.2XP_038942804.1  tRNA-splicing endonuclease subunit Sen54 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AEJ0
      Related
      ENSRNOP00000091908.2, ENSRNOT00000098924.2
      Conserved Domains (2) summary
      pfam12928
      Location:67134
      tRNA_int_end_N2; tRNA-splicing endonuclease subunit sen54 N-term
      cl40623
      Location:120191
      tRNA_int_end_N2; tRNA-splicing endonuclease subunit sen54 N-term
    3. XM_039086875.2XP_038942803.1  tRNA-splicing endonuclease subunit Sen54 isoform X3

      Conserved Domains (2) summary
      pfam12928
      Location:67134
      tRNA_int_end_N2; tRNA-splicing endonuclease subunit sen54 N-term
      cl40623
      Location:120173
      tRNA_int_end_N2; tRNA-splicing endonuclease subunit sen54 N-term
    4. XM_006247737.5XP_006247799.1  tRNA-splicing endonuclease subunit Sen54 isoform X2

      Related
      ENSRNOP00000111015.1, ENSRNOT00000137395.1
      Conserved Domains (1) summary
      pfam12928
      Location:63130
      tRNA_int_end_N2; tRNA-splicing endonuclease subunit sen54 N-term
    5. XM_063269886.1XP_063125956.1  tRNA-splicing endonuclease subunit Sen54 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AEJ0
      Related
      ENSRNOP00000006327.3, ENSRNOT00000006327.6

    RNA

    1. XR_005489949.2 RNA Sequence

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