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    Hdac11 histone deacetylase 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297453, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hdac11provided by RGD
    Official Full Name
    histone deacetylase 11provided by RGD
    Primary source
    RGD:1311706
    See related
    EnsemblRapid:ENSRNOG00000006824 AllianceGenome:RGD:1311706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone deacetylase activity. Involved in oligodendrocyte development. Predicted to be located in nucleus and plasma membrane. Predicted to be part of histone deacetylase complex. Orthologous to human HDAC11 (histone deacetylase 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 355.0), Kidney (RPKM 92.9) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Hdac11 in Genome Data Viewer
    Location:
    4q34
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (125203044..125224584)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (123645873..123667407)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (122781095..122798355)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene IQ motif and Sec7 domain ArfGEF 1 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene nucleoporin 210 Neighboring gene uncharacterized LOC134486816 Neighboring gene fibulin 2 Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone deacetylase 11 regulates oligodendrocyte-specific gene expression and cell development in OL-1 oligodendroglia cells. Liu H, et al. Glia, 2009 Jan 1. PMID 18627006, Free PMC Article
    2. Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family. Gao L, et al. J Biol Chem, 2002 Jul 12. PMID 11948178
    3. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A, et al. J Biomed Biotechnol, 2011. PMID 21151613, Free PMC Article
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interaction of HDAC11 with acetylated histone H3 markedly increases oligodendrocyte-specific gene expression in developing cells.
      Title: Histone deacetylase 11 regulates oligodendrocyte-specific gene expression and cell development in OL-1 oligodendroglia cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone deacetylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in oligodendrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone deacetylase 11
    NP_001100080.2
    XP_038963301.1
    XP_038963302.1
    XP_038963304.1
    XP_063141890.1
    XP_063141891.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106610.2 → NP_001100080.2  histone deacetylase 11

      See identical proteins and their annotated locations for NP_001100080.2

      Status: VALIDATED

      Source sequence(s)
      BC166430, CN540732
      UniProtKB/TrEMBL
      B2GUW3, F7EU26
      Related
      ENSRNOP00000008962.5, ENSRNOT00000008962.8
      Conserved Domains (1) summary
      cd09993
      Location:35 → 319
      HDAC_classIV; Histone deacetylase class IV also known as histone deacetylase 11

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      125203044..125224584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107373.1 → XP_038963301.1  histone deacetylase 11 isoform X2

      Related
      ENSRNOP00000094660.2, ENSRNOT00000108276.2
      Conserved Domains (1) summary
      cd09993
      Location:7 → 291
      HDAC_classIV; Histone deacetylase class IV also known as histone deacetylase 11

    2. XM_063285821.1 → XP_063141891.1  histone deacetylase 11 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ALH9

    3. XM_063285820.1 → XP_063141890.1  histone deacetylase 11 isoform X1

    4. XM_039107374.2 → XP_038963302.1  histone deacetylase 11 isoform X2

      Conserved Domains (1) summary
      cd09993
      Location:7 → 291
      HDAC_classIV; Histone deacetylase class IV also known as histone deacetylase 11

    5. XM_039107376.2 → XP_038963304.1  histone deacetylase 11 isoform X4

      UniProtKB/TrEMBL
      A6IB92
      Conserved Domains (1) summary
      cl17011
      Location:1 → 158
      Arginase_HDAC; Arginase-like and histone-like hydrolases
    Nucleotide Protein Strain
    Heading Accession and Version

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