Parp11 poly (ADP-ribose) polymerase family, member 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Parp11provided by RGD
Official Full Name: poly (ADP-ribose) polymerase family, member 11provided by RGD
Primary source: RGD:1561791
See related: EnsemblRapid:ENSRNOG00000060689 AllianceGenome:RGD:1561791
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1561791
Summary: Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Predicted to be involved in protein auto-ADP-ribosylation. Predicted to act upstream of or within nuclear envelope organization. Predicted to be located in cytosol; nuclear body; and nuclear envelope. Predicted to be active in nucleus. Orthologous to human PARP11 (poly(ADP-ribose) polymerase family member 11). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 40.2), Brain (RPKM 29.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (161984192..162030550)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (160298040..160344369)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (160013968..160059981)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within nuclear envelope organization	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP11

Names: poly [ADP-ribose] polymerase 11

NP_001414716.1

EC 2.4.2.30

XP_038964754.1

EC 2.4.2.30

XP_038964757.1

EC 2.4.2.30

XP_038964758.1

EC 2.4.2.30

XP_038964760.1

EC 2.4.2.30

XP_063142641.1

EC 2.4.2.30

XP_063142642.1

EC 2.4.2.30

XP_063142643.1

EC 2.4.2.30

XP_063142644.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427787.2 → NP_001414716.1 protein mono-ADP-ribosyltransferase PARP11

Status: VALIDATED

Source sequence(s)

JAXUCZ010000004

UniProtKB/TrEMBL

A0A0G2JTL9

Related

ENSRNOP00000068762.2, ENSRNOT00000078802.3

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

161984192..162030550

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286574.1 → XP_063142644.1 protein mono-ADP-ribosyltransferase PARP11 isoform X5
XM_063286571.1 → XP_063142641.1 protein mono-ADP-ribosyltransferase PARP11 isoform X2
XM_063286573.1 → XP_063142643.1 protein mono-ADP-ribosyltransferase PARP11 isoform X3
XM_039108830.2 → XP_038964758.1 protein mono-ADP-ribosyltransferase PARP11 isoform X3

Conserved Domains (1) summary

cd01439
Location:111 → 247

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_039108826.2 → XP_038964754.1 protein mono-ADP-ribosyltransferase PARP11 isoform X1

UniProtKB/TrEMBL

A0A0G2JTL9

Conserved Domains (2) summary

smart00678
Location:27 → 107

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd01439
Location:194 → 330

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_039108829.2 → XP_038964757.1 protein mono-ADP-ribosyltransferase PARP11 isoform X3

Conserved Domains (1) summary

cd01439
Location:111 → 247

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...
XM_063286572.1 → XP_063142642.1 protein mono-ADP-ribosyltransferase PARP11 isoform X3
XM_039108832.2 → XP_038964760.1 protein mono-ADP-ribosyltransferase PARP11 isoform X4

Conserved Domains (1) summary

cd01439
Location:77 → 213

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...