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    Gpr88 G-protein coupled receptor 88 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64443, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr88provided by RGD
    Official Full Name
    G-protein coupled receptor 88provided by RGD
    Primary source
    RGD:61921
    See related
    EnsemblRapid:ENSRNOG00000026953 AllianceGenome:RGD:61921
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G protein-coupled photoreceptor activity; beta2-adrenergic receptor activity; and cytoskeletal motor activity. Predicted to be involved in several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; motor learning; and phototransduction. Predicted to act upstream of or within locomotory behavior; neuromuscular process controlling balance; and neuronal action potential. Located in cytoplasm; nucleus; and plasma membrane. Orthologous to human GPR88 (G protein-coupled receptor 88). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 104.7), Spleen (RPKM 91.8) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gpr88 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (206876373..206885034, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (204191443..204199576, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (219258346..219263819, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120100924 Neighboring gene uncharacterized LOC134485676 Neighboring gene uncharacterized LOC134485677 Neighboring gene cell division cycle 14A Neighboring gene uncharacterized LOC120100925

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease. Galet B, et al. J Psychiatry Neurosci, 2021 Jan 4. PMID 32667145, Free PMC Article
    2. Developmental and adult expression patterns of the G-protein-coupled receptor GPR88 in the rat: Establishment of a dual nuclear-cytoplasmic localization. Massart R, et al. J Comp Neurol, 2016 Oct 1. PMID 26918661
    3. Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats. Ingallinesi M, et al. Mol Psychiatry, 2015 Aug. PMID 25155879
    4. Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents. Massart R, et al. Eur J Neurosci, 2009 Aug. PMID 19656174
    5. Possible involvement of orphan receptors GPR88 and GPR124 in the development of hypertension in spontaneously hypertensive rat. Calderón-Zamora L, et al. Clin Exp Hypertens, 2017. PMID 28678544

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease.
      Title: G-protein coupled receptor 88 knockdown in the associative striatum reduces psychiatric symptoms in a translational male rat model of Parkinson disease.
    2. Therefore, we conclude that GPR88 and GPR124 receptors may be involved in the development or maintenance of high blood pressure.
      Title: Possible involvement of orphan receptors GPR88 and GPR124 in the development of hypertension in spontaneously hypertensive rat.
    3. In the developing cortex, GPR88 shifts on the day of birth to the nuclei of neurons in layers V to II.
      Title: Developmental and adult expression patterns of the G-protein-coupled receptor GPR88 in the rat: Establishment of a dual nuclear-cytoplasmic localization.
    4. Results suggest a role for Gpr88 in the regulation of cognitive and motor functions, and support its relevance to the pathophysiology and treatment of schizophrenia and other disorders involving dysfunction of the accumbens-striatal complex
      Title: Local inactivation of Gpr88 in the nucleus accumbens attenuates behavioral deficits elicited by the neonatal administration of phencyclidine in rats.
    5. GPR88 is confined to striatal medium spiny neurons and indicate that L-DOPA-mediated behavioural effects in hemiparkinsonian rats may involve normalization of striatal GPR88 levels
      Title: Striatal GPR88 expression is confined to the whole projection neuron population and is regulated by dopaminergic and glutamatergic afferents.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled photoreceptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta2-adrenergic receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta2-adrenergic receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables cytoskeletal motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cytoskeletal motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in adrenergic receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to light stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of visible light IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in motor learning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in motor learning ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phototransduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in ciliary membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    G protein-coupled receptor 88
    Names
    probable G-protein coupled receptor 88
    striatum-specific G-protein coupled receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031696.2 → NP_113884.1  G protein-coupled receptor 88

      See identical proteins and their annotated locations for NP_113884.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9ESP4
      UniProtKB/TrEMBL
      A6HV91
      Conserved Domains (2) summary
      cd14964
      Location:33 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 347
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      206876373..206885034 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039103063.2 → XP_038958991.1  G protein-coupled receptor 88 isoform X1

      UniProtKB/Swiss-Prot
      Q9ESP4
      UniProtKB/TrEMBL
      A6HV91
      Related
      ENSRNOP00000100418.1, ENSRNOT00000141206.1
      Conserved Domains (2) summary
      cd14964
      Location:33 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 347
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    2. XM_039103064.2 → XP_038958992.1  G protein-coupled receptor 88 isoform X1

      UniProtKB/Swiss-Prot
      Q9ESP4
      UniProtKB/TrEMBL
      A6HV91
      Related
      ENSRNOP00000038233.2, ENSRNOT00000037068.5
      Conserved Domains (2) summary
      cd14964
      Location:33 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 347
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    3. XM_039103062.2 → XP_038958990.1  G protein-coupled receptor 88 isoform X1

      UniProtKB/Swiss-Prot
      Q9ESP4
      UniProtKB/TrEMBL
      A6HV91
      Conserved Domains (2) summary
      cd14964
      Location:33 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 347
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    4. XM_039103061.2 → XP_038958989.1  G protein-coupled receptor 88 isoform X1

      UniProtKB/Swiss-Prot
      Q9ESP4
      UniProtKB/TrEMBL
      A6HV91
      Related
      ENSRNOP00000111907.1, ENSRNOT00000167227.1
      Conserved Domains (2) summary
      cd14964
      Location:33 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 347
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    5. XM_006233222.5 → XP_006233284.1  G protein-coupled receptor 88 isoform X1

      See identical proteins and their annotated locations for XP_006233284.1

      UniProtKB/Swiss-Prot
      Q9ESP4
      UniProtKB/TrEMBL
      A6HV91
      Conserved Domains (2) summary
      cd14964
      Location:33 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 347
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    6. XM_006233221.5 → XP_006233283.1  G protein-coupled receptor 88 isoform X1

      See identical proteins and their annotated locations for XP_006233283.1

      UniProtKB/Swiss-Prot
      Q9ESP4
      UniProtKB/TrEMBL
      A6HV91
      Related
      ENSRNOP00000101034.1, ENSRNOT00000129009.1
      Conserved Domains (2) summary
      cd14964
      Location:33 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 347
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

    7. XM_006233220.5 → XP_006233282.1  G protein-coupled receptor 88 isoform X1

      See identical proteins and their annotated locations for XP_006233282.1

      UniProtKB/Swiss-Prot
      Q9ESP4
      UniProtKB/TrEMBL
      A6HV91
      Conserved Domains (2) summary
      cd14964
      Location:33 → 59
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:33 → 347
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ESP4.1 GenPept UniProtKB/Swiss-Prot:Q9ESP4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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