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    Thtpa thiamine triphosphatase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305889, updated on 9-Dec-2024

    Summary

    Official Symbol
    Thtpaprovided by RGD
    Official Full Name
    thiamine triphosphataseprovided by RGD
    Primary source
    RGD:727917
    See related
    EnsemblRapid:ENSRNOG00000018105 AllianceGenome:RGD:727917
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable magnesium ion binding activity and thiamine triphosphate phosphatase activity. Predicted to be involved in dephosphorylation and thiamine diphosphate biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human THTPA (thiamine triphosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 166.2), Kidney (RPKM 72.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Thtpa in Genome Data Viewer
    Location:
    15p13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32536297..32541537)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28567619..28571580)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33755157..33759117)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene neuroguidin Neighboring gene uncharacterized LOC134482119 Neighboring gene zinc finger homeobox 2 Neighboring gene adaptor related protein complex 1 subunit gamma 2 Neighboring gene junctophilin 4 Neighboring gene dehydrogenase/reductase member 2 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC94155

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables metal ion binding  
    enables thiamine triphosphate phosphatase activity  
    enables thiamine triphosphate phosphatase activity  
    enables thiamine triphosphate phosphatase activity  
    enables thiamine triphosphate phosphatase activity  
    Process Evidence Code Pubs
    involved_in dephosphorylation  
    involved_in thiamine diphosphate biosynthetic process  
    involved_in thiamine diphosphate biosynthetic process  
    involved_in thiamine diphosphate metabolic process  
    involved_in thiamine diphosphate metabolic process  
    involved_in thiamine diphosphate metabolic process  
    involved_in thiamine metabolic process  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in cytosol  
    is_active_in cytosol  

    General protein information

    Preferred Names
    thiamine-triphosphatase
    Names
    thTPase
    NP_001007683.1
    XP_006252032.1
    XP_063130321.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007682.1NP_001007683.1  thiamine-triphosphatase

      See identical proteins and their annotated locations for NP_001007683.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081978
      UniProtKB/Swiss-Prot
      Q8CGV7
      UniProtKB/TrEMBL
      A0A0G2JTF6, A6KGY7
      Related
      ENSRNOP00000096778.2, ENSRNOT00000105427.2
      Conserved Domains (1) summary
      cd07758
      Location:6198
      ThTPase; Thiamine Triphosphatase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      32536297..32541537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251970.5XP_006252032.1  thiamine-triphosphatase isoform X2

      UniProtKB/TrEMBL
      A0A0G2JTF6, A0A8I6ASR1
      Conserved Domains (1) summary
      cd07758
      Location:6184
      ThTPase; Thiamine Triphosphatase
    2. XM_063274251.1XP_063130321.1  thiamine-triphosphatase isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTF6, A0A8I6AT66
      Related
      ENSRNOP00000106859.1, ENSRNOT00000136381.1
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