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    Ybx2 Y box binding protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303250, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ybx2provided by RGD
    Official Full Name
    Y box binding protein 2provided by RGD
    Primary source
    RGD:1305068
    See related
    EnsemblRapid:ENSRNOG00000017117 AllianceGenome:RGD:1305068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305068
    Summary
    Predicted to enable several functions, including chromatin binding activity; mRNA 3'-UTR binding activity; and ribonucleoprotein complex binding activity. Involved in oocyte development. Predicted to be located in cytoplasm. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleus. Orthologous to human YBX2 (Y-box binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 1092.8) and Thymus (RPKM 46.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ybx2 in Genome Data Viewer
    Location:
    10q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (55158420..55164077)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (54659719..54665371)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (56546689..56552339)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene neuralized E3 ubiquitin protein ligase 4 Neighboring gene G protein pathway suppressor 2 Neighboring gene eukaryotic translation initiation factor 5A Neighboring gene solute carrier family 2 member 4 Neighboring gene cofilin-1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In the absence of the mouse DNA/RNA-binding protein MSY2, messenger RNA instability leads to spermatogenic arrest. Yang J, et al. Biol Reprod, 2007 Jan. PMID 17035640
    2. Loss of synaptonemal complex protein-1, a synaptonemal complex protein, contributes to the initiation of follicular assembly in the developing rat ovary. Paredes A, et al. Endocrinology, 2005 Dec. PMID 16150897
    3. Absence of the DNA-/RNA-binding protein MSY2 results in male and female infertility. Yang J, et al. Proc Natl Acad Sci U S A, 2005 Apr 19. PMID 15824319, Free PMC Article
    4. Requirement for RNA-binding activity of MSY2 for cytoplasmic localization and retention in mouse oocytes. Yu J, et al. Dev Biol, 2003 Mar 15. PMID 12648488
    5. RNA-binding properties and translation repression in vitro by germ cell-specific MSY2 protein. Yu J, et al. Biol Reprod, 2002 Oct. PMID 12297523

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonucleoprotein complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oocyte development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within oogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within spermatid development ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    Y-box-binding protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305212.2 → NP_001292141.1  Y-box-binding protein 2

      Status: VALIDATED

      Source sequence(s)
      CK597131, JAXUCZ010000010
      UniProtKB/TrEMBL
      D4A3P0
      Related
      ENSRNOP00000023003.3, ENSRNOT00000023003.8
      Conserved Domains (1) summary
      pfam00313
      Location:95 → 164
      CSD; 'Cold-shock' DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      55158420..55164077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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