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    Tlx3 T-cell leukemia, homeobox 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497881, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tlx3provided by RGD
    Official Full Name
    T-cell leukemia, homeobox 3provided by RGD
    Primary source
    RGD:1564190
    See related
    EnsemblRapid:ENSRNOG00000004976 AllianceGenome:RGD:1564190
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564190
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal organ development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including nervous system development; regulation of respiratory gaseous exchange by nervous system process; and respiratory gaseous exchange by respiratory system. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Orthologous to human TLX3 (T cell leukemia homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 4.7) See more
    Orthologs
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    Genomic context

    See Tlx3 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (18293932..18296551, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (17789706..17792207, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (18128869..18131745, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor 18 Neighboring gene uncharacterized LOC102546482 Neighboring gene nucleophosmin 1 Neighboring gene RAN binding protein 17 Neighboring gene spindle and kinetochore-associated protein 2 pseudogene Neighboring gene uncharacterized LOC108352198 Neighboring gene gamma-aminobutyric acid type A receptor subunit pi

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    T-cell leukemia homeobox protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427590.1 → NP_001414519.1  T-cell leukemia homeobox protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HDG5, G3V6M6
      Related
      ENSRNOP00000006676.6, ENSRNOT00000006676.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      18293932..18296551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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