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    Cnot6l CCR4-NOT transcription complex, subunit 6-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360917, updated on 27-Dec-2024

    Summary

    Official Symbol
    Cnot6lprovided by RGD
    Official Full Name
    CCR4-NOT transcription complex, subunit 6-likeprovided by RGD
    Primary source
    RGD:1309128
    See related
    EnsemblRapid:ENSRNOG00000002075 AllianceGenome:RGD:1309128
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in positive regulation of cytoplasmic mRNA processing body assembly. Predicted to act upstream of or within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay and positive regulation of cell population proliferation. Predicted to be located in cytosol and nucleus. Predicted to be part of CCR4-NOT complex. Orthologous to human CNOT6L (CCR4-NOT transcription complex subunit 6 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 122.5), Lung (RPKM 120.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Cnot6l in Genome Data Viewer
    Location:
    14p22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (13714475..13806481)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (13410499..13502511)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (15059101..15148255)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120096573 Neighboring gene mitochondrial ribosomal protein L1 Neighboring gene U2 spliceosomal RNA Neighboring gene C-X-C motif chemokine ligand 13 Neighboring gene PRAME family member 20, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5'-RNA exonuclease activity  
    enables metal ion binding  
    enables poly(A)-specific ribonuclease activity  
    Component Evidence Code Pubs
    part_of CCR4-NOT complex  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in nucleus  

    General protein information

    Preferred Names
    CCR4-NOT transcription complex subunit 6-like
    NP_001101825.1
    NP_001401900.1
    NP_001402023.1
    XP_006250770.1
    XP_038948089.1
    XP_038948090.1
    XP_038948092.1
    XP_063129404.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108355.3NP_001101825.1  CCR4-NOT transcription complex subunit 6-like isoform 1

      See identical proteins and their annotated locations for NP_001101825.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6A149, A6K672, F1M642
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    2. NM_001414971.2NP_001401900.1  CCR4-NOT transcription complex subunit 6-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
    3. NM_001415094.2NP_001402023.1  CCR4-NOT transcription complex subunit 6-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000014
      UniProtKB/TrEMBL
      A0A8I6A149, A6K672, F1M642
      Related
      ENSRNOP00000085884.2, ENSRNOT00000101961.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      13714475..13806481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092162.2XP_038948090.1  CCR4-NOT transcription complex subunit 6-like isoform X2

      UniProtKB/TrEMBL
      A0A8I6A149, A6K672, F1M642
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    2. XM_006250708.5XP_006250770.1  CCR4-NOT transcription complex subunit 6-like isoform X1

      See identical proteins and their annotated locations for XP_006250770.1

      UniProtKB/TrEMBL
      A0A8I6A149
      Related
      ENSRNOP00000002843.6, ENSRNOT00000002843.7
      Conserved Domains (3) summary
      cd10312
      Location:191538
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:57183
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3857
      LRR_1; leucine-rich repeat [structural motif]
    3. XM_039092161.2XP_038948089.1  CCR4-NOT transcription complex subunit 6-like isoform X2

      UniProtKB/TrEMBL
      A0A8I6A149, A6K672, F1M642
      Conserved Domains (3) summary
      cd10312
      Location:186533
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
      COG4886
      Location:52178
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00031
      Location:3352
      LRR_1; leucine-rich repeat [structural motif]
    4. XM_063273334.1XP_063129404.1  CCR4-NOT transcription complex subunit 6-like isoform X2

      UniProtKB/TrEMBL
      A0A8I6A149, A6K672, F1M642
      Related
      ENSRNOP00000096187.2, ENSRNOT00000117565.2
    5. XM_039092164.2XP_038948092.1  CCR4-NOT transcription complex subunit 6-like isoform X3

      Conserved Domains (1) summary
      cd10312
      Location:50397
      Deadenylase_CCR4b; C-terminal deadenylase domain of CCR4b, also known as CCR4-NOT transcription complex subunit 6-like
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