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    Mier3 MIER family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310086, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mier3provided by RGD
    Official Full Name
    MIER family member 3provided by RGD
    Primary source
    RGD:1311241
    See related
    EnsemblRapid:ENSRNOG00000013121 AllianceGenome:RGD:1311241
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311241
    Summary
    Predicted to enable histone deacetylase binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of protein-containing complex. Predicted to be active in nucleoplasm. Orthologous to human MIER3 (MIER family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 158.8), Spleen (RPKM 114.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mier3 in Genome Data Viewer
    Location:
    2q14
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (45021167..45049745)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (43287546..43316422)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (43266301..43295175)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 68 Neighboring gene uncharacterized LOC134485835 Neighboring gene activated RNA polymerase II transcriptional coactivator p15 pseudogene Neighboring gene SET domain containing, pseudogene 1 Neighboring gene uncharacterized LOC134485836

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MIER3 suppresses the progression of non-small cell lung cancer by inhibiting Wnt/β-Catenin pathway and histone acetyltransferase activity. Zhang H, et al. Transl Cancer Res, 2020 Jan. PMID 35117188, Free PMC Article
    2. MIER3 induces epithelial-mesenchymal transition and promotes breast cancer cell aggressiveness via forming a co-repressor complex with HDAC1/HDAC2/Snail. Huang W, et al. Exp Cell Res, 2021 Sep 1. PMID 34242623
    3. Differential HDAC1 and 2 Recruitment by Members of the MIER Family. Derwish R, et al. PLoS One, 2017. PMID 28046085, Free PMC Article
    4. Rat Mcs1b is concordant to the genome-wide association-identified breast cancer risk locus at human 5q11.2 and MIER3 is a candidate cancer susceptibility gene. denDekker AD, et al. Cancer Res, 2012 Nov 15. PMID 22993404, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT contributes_to histone deacetylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mesoderm induction early response protein 3
    Names
    mesoderm induction early response 1, family member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168000.2 → NP_001161472.1  mesoderm induction early response protein 3

      See identical proteins and their annotated locations for NP_001161472.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I5N1, D3ZE77
      Conserved Domains (2) summary
      cd11661
      Location:255 → 299
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:149 → 197
      ELM2; ELM2 domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      45021167..45049745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231925.4 → XP_006231987.3  mesoderm induction early response protein 3 isoform X2

      UniProtKB/TrEMBL
      A6I5N1, D3ZE77

    2. XM_006231924.5 → XP_006231986.1  mesoderm induction early response protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JUL8, D3ZE77
      Related
      ENSRNOP00000069147.1, ENSRNOT00000087031.3
      Conserved Domains (3) summary
      smart00717
      Location:280 → 327
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11661
      Location:282 → 326
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:176 → 224
      ELM2; ELM2 domain

    3. XM_039102181.2 → XP_038958109.1  mesoderm induction early response protein 3 isoform X2

      UniProtKB/TrEMBL
      A6I5N1, D3ZE77
      Conserved Domains (2) summary
      cd11661
      Location:255 → 299
      SANT_MTA3_like; Myb-Like Dna-Binding Domain of MTA3 and related proteins
      pfam01448
      Location:149 → 197
      ELM2; ELM2 domain

    4. XM_063281723.1 → XP_063137793.1  mesoderm induction early response protein 3 isoform X2

      UniProtKB/TrEMBL
      A6I5N1, D3ZE77

    RNA

    1. XR_010063601.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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