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    Gpr153 G protein-coupled receptor 153 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 619550, updated on 9-Dec-2024

    Summary

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    Symbol
    Gpr153provided by RGD
    Full Name
    G protein-coupled receptor 153provided by RGD
    Primary source
    RGD:1564170
    See related
    EnsemblRapid:ENSRNOG00000010718 AllianceGenome:RGD:1564170
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Orthologous to human GPR153 (G protein-coupled receptor 153). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 27.5), Uterus (RPKM 21.5) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
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    Genomic context

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    See Gpr153 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (168064134..168075697)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162781587..162792975)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169450275..169463878)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487047 Neighboring gene acyl-CoA thioesterase 7 Neighboring gene hes family bHLH transcription factor 3 Neighboring gene isoprenylcysteine carboxyl methyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus. Sreedharan S, et al. FEBS J, 2011 Dec. PMID 21981325
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. antisense oligodeoxynucleotide knockdown of Gpr153 caused a slight reduction in food intake and elevated plus maze test showed significant reduction in the percentage of time spent in centre square, which points towards probable role in decision making.
      Title: The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable G-protein coupled receptor 153

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034855.1 → NP_001030027.1  probable G-protein coupled receptor 153

      See identical proteins and their annotated locations for NP_001030027.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105872
      UniProtKB/TrEMBL
      A0A8J8Y8J7
      Conserved Domains (1) summary
      pfam00001
      Location:29 → 223
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      168064134..168075697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006239485.5 → XP_006239547.1  probable G-protein coupled receptor 153 isoform X1

      See identical proteins and their annotated locations for XP_006239547.1

      UniProtKB/TrEMBL
      A6IUH7
      Related
      ENSRNOP00000014444.7, ENSRNOT00000014444.8
      Conserved Domains (1) summary
      pfam00001
      Location:29 → 219
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    2. XM_006239486.5 → XP_006239548.1  probable G-protein coupled receptor 153 isoform X2

      UniProtKB/TrEMBL
      D4ABT6, Q3KR68
      Conserved Domains (2) summary
      cd14964
      Location:9 → 35
      7tm_GPCRs; TM helix 1 [structural motif]
      cl28897
      Location:8 → 308
      7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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