Ripor2 RHO family interacting cell polarization regulator 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ripor2provided by RGD
Official Full Name: RHO family interacting cell polarization regulator 2provided by RGD
Primary source: RGD:1306939
See related: EnsemblRapid:ENSRNOG00000018804 AllianceGenome:RGD:1306939
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam65b; Ab2-162; RGD1306939
Summary: Predicted to enable 14-3-3 protein binding activity and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of T cell activation; positive regulation of cellular component organization; and regulation of leukocyte migration. Located in apical plasma membrane and stereocilium membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 21 and autosomal recessive nonsyndromic deafness 104. Orthologous to human RIPOR2 (RHO family interacting cell polarization regulator 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 497.7), Kidney (RPKM 338.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p11

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (40751771..40975611, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (40323748..40547482, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (42324594..42549907, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables 14-3-3 protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables ferric iron binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in auditory receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cellular response to chemokine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to chemokine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in establishment of protein localization	ISO Inferred from Sequence Orthology more info
involved_in muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of Rho guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rho guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rho protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of establishment of T cell polarity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of establishment of T cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein localization to cell leading edge	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myoblast fusion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast fusion	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neutrophil extravasation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil extravasation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in regulation of establishment of cell polarity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in filopodium	ISO Inferred from Sequence Orthology more info
located_in filopodium	ISS Inferred from Sequence or Structural Similarity more info
located_in stereocilium	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium	ISO Inferred from Sequence Orthology more info
located_in stereocilium membrane	IDA Inferred from Direct Assay more info	PubMed
located_in stereocilium membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rho family-interacting cell polarization regulator 2

Names: family with sequence similarity 65, member B; protein FAM65B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014009.3 → NP_001014031.2 rho family-interacting cell polarization regulator 2

See identical proteins and their annotated locations for NP_001014031.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q7TP54

Related

ENSRNOP00000048390.1, ENSRNOT00000048298.3

Conserved Domains (4) summary

pfam00210
Location:1164 → 1282

Ferritin; Ferritin-like domain

pfam15903
Location:118 → 529

PL48; Filopodia upregulated, FAM65

cl00264
Location:1160 → 1304

Ferritin_like; Ferritin-like superfamily of diiron-containing four-helix-bundle proteins

cl14615
Location:963 → 1097

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

40751771..40975611 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017600533.3 → XP_017456022.1 rho family-interacting cell polarization regulator 2 isoform X6

UniProtKB/TrEMBL

A6KLG3
XM_017600530.3 → XP_017456019.1 rho family-interacting cell polarization regulator 2 isoform X1

UniProtKB/TrEMBL

A6KLG4
XM_017600531.3 → XP_017456020.1 rho family-interacting cell polarization regulator 2 isoform X2

UniProtKB/TrEMBL

A6KLG4
XM_063276412.1 → XP_063132482.1 rho family-interacting cell polarization regulator 2 isoform X7

UniProtKB/TrEMBL

A6KLG3
XM_006253929.5 → XP_006253991.1 rho family-interacting cell polarization regulator 2 isoform X3

UniProtKB/TrEMBL

A6KLG4

Conserved Domains (3) summary

pfam15903
Location:45 → 392

PL48; Filopodia upregulated, FAM65

sd00044
Location:960 → 981

HEAT; HEAT repeat [structural motif]

cl14615
Location:869 → 1003

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
XM_063276413.1 → XP_063132483.1 rho family-interacting cell polarization regulator 2 isoform X8

UniProtKB/TrEMBL

A6KLG3
XM_006253930.3 → XP_006253992.1 rho family-interacting cell polarization regulator 2 isoform X4

UniProtKB/TrEMBL

A0A8I5Y5T3, A6KLG4

Related

ENSRNOP00000082516.1, ENSRNOT00000110402.2

Conserved Domains (3) summary

pfam15903
Location:41 → 388

PL48; Filopodia upregulated, FAM65

sd00044
Location:956 → 977

HEAT; HEAT repeat [structural motif]

cl14615
Location:865 → 999

PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
XM_063276414.1 → XP_063132484.1 rho family-interacting cell polarization regulator 2 isoform X9

UniProtKB/TrEMBL

A0A8I5Y5T3, A6KLG4

Related

ENSRNOP00000077001.1, ENSRNOT00000117811.2
XM_063276411.1 → XP_063132481.1 rho family-interacting cell polarization regulator 2 isoform X5

UniProtKB/TrEMBL

A0A8I6GLY0, A6KLG4
XM_017600535.3 → XP_017456024.1 rho family-interacting cell polarization regulator 2 isoform X12

UniProtKB/TrEMBL

A0A8I6AP27, A6KLG7

Related

ENSRNOP00000096012.1, ENSRNOT00000102510.2
XM_017600534.3 → XP_017456023.1 rho family-interacting cell polarization regulator 2 isoform X10

UniProtKB/TrEMBL

A6KLG8
XM_063276416.1 → XP_063132486.1 rho family-interacting cell polarization regulator 2 isoform X13

UniProtKB/TrEMBL

A0A8I5ZX07, A6KLG7

Related

ENSRNOP00000083444.1, ENSRNOT00000117790.2
XM_063276417.1 → XP_063132487.1 rho family-interacting cell polarization regulator 2 isoform X14

UniProtKB/TrEMBL

A6KLG7
XM_063276415.1 → XP_063132485.1 rho family-interacting cell polarization regulator 2 isoform X11

UniProtKB/TrEMBL

A0A8I6AQC8, A6KLG8

Related

ENSRNOP00000096913.1, ENSRNOT00000101796.2