Ssh3 slingshot protein phosphatase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ssh3provided by RGD
Official Full Name: slingshot protein phosphatase 3provided by RGD
Primary source: RGD:1308679
See related: EnsemblRapid:ENSRNOG00000018878 AllianceGenome:RGD:1308679
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin binding activity and phosphoprotein phosphatase activity. Predicted to be involved in actin cytoskeleton organization and negative regulation of actin filament polymerization. Predicted to be located in cytoskeleton and nucleus. Predicted to be active in cytoplasm. Orthologous to human SSH3 (slingshot protein phosphatase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 110.7), Kidney (RPKM 89.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (210986604..210994975, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (201557167..201565577, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (219511908..219519398, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BF399542 (e-PCR)
- UniSTS:247715

AA926337 (e-PCR)
- UniSTS:243382

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables MAP kinase serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables actin binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS140 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity, metal-dependent	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of actin filament polymerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein phosphatase Slingshot homolog 3

Names: SSH-3L; SSH-like protein 3; slingshot homolog 3

NP_001012217.1

EC 3.1.3.16

EC 3.1.3.48

XP_038941428.1

EC 3.1.3.16

EC 3.1.3.48

XP_038941431.1

EC 3.1.3.16

EC 3.1.3.48

XP_038941444.1

EC 3.1.3.16

EC 3.1.3.48

XP_038941454.1

EC 3.1.3.16

EC 3.1.3.48

XP_038941487.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125903.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125906.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125910.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125914.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125917.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125918.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125925.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125928.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125929.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125931.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125932.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125934.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125939.1

EC 3.1.3.16

EC 3.1.3.48

XP_063125941.1

EC 3.1.3.16

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012217.1 → NP_001012217.1 protein phosphatase Slingshot homolog 3

See identical proteins and their annotated locations for NP_001012217.1

Status: PROVISIONAL

Source sequence(s)

BC083600

UniProtKB/Swiss-Prot

Q5XIS1

Related

ENSRNOP00000025546.8, ENSRNOT00000025546.8

Conserved Domains (3) summary

cd11652
Location:3 → 256

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd00127
Location:326 → 461

DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

pfam08766
Location:269 → 317

DEK_C; DEK C terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

210986604..210994975 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269844.1 → XP_063125914.1 protein phosphatase Slingshot homolog 3 isoform X7
XM_063269833.1 → XP_063125903.1 protein phosphatase Slingshot homolog 3 isoform X3
XM_039085503.2 → XP_038941431.1 protein phosphatase Slingshot homolog 3 isoform X2

Conserved Domains (3) summary

cd11652
Location:32 → 279

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd14571
Location:350 → 493

DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3

pfam08766
Location:296 → 347

DEK_C; DEK C terminal domain
XM_039085500.2 → XP_038941428.1 protein phosphatase Slingshot homolog 3 isoform X1

Conserved Domains (3) summary

cd11652
Location:32 → 279

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd14571
Location:352 → 495

DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3

pfam08766
Location:298 → 349

DEK_C; DEK C terminal domain
XM_063269847.1 → XP_063125917.1 protein phosphatase Slingshot homolog 3 isoform X9
XM_063269861.1 → XP_063125931.1 protein phosphatase Slingshot homolog 3 isoform X14
XM_063269859.1 → XP_063125929.1 protein phosphatase Slingshot homolog 3 isoform X13
XM_063269855.1 → XP_063125925.1 protein phosphatase Slingshot homolog 3 isoform X11

Related

ENSRNOP00000106566.1, ENSRNOT00000173405.1
XM_063269840.1 → XP_063125910.1 protein phosphatase Slingshot homolog 3 isoform X5
XM_063269862.1 → XP_063125932.1 protein phosphatase Slingshot homolog 3 isoform X14
XM_063269858.1 → XP_063125928.1 protein phosphatase Slingshot homolog 3 isoform X12
XM_063269848.1 → XP_063125918.1 protein phosphatase Slingshot homolog 3 isoform X10
XM_039085526.2 → XP_038941454.1 protein phosphatase Slingshot homolog 3 isoform X8

UniProtKB/TrEMBL

A6HYW8

Conserved Domains (3) summary

cd11652
Location:3 → 257

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd14571
Location:324 → 467

DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3

pfam08766
Location:270 → 321

DEK_C; DEK C terminal domain
XM_039085516.2 → XP_038941444.1 protein phosphatase Slingshot homolog 3 isoform X6

UniProtKB/TrEMBL

F1LR78

Conserved Domains (3) summary

cd11652
Location:3 → 257

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

cd14571
Location:328 → 471

DSP_slingshot_3; dual specificity phosphatase domain of slingshot homolog 3

pfam08766
Location:274 → 325

DEK_C; DEK C terminal domain
XM_063269836.1 → XP_063125906.1 protein phosphatase Slingshot homolog 3 isoform X4
XM_063269864.1 → XP_063125934.1 protein phosphatase Slingshot homolog 3 isoform X15
XM_063269871.1 → XP_063125941.1 protein phosphatase Slingshot homolog 3 isoform X16
XM_063269869.1 → XP_063125939.1 protein phosphatase Slingshot homolog 3 isoform X16
XM_039085559.2 → XP_038941487.1 protein phosphatase Slingshot homolog 3 isoform X17

Conserved Domains (3) summary

cd11652
Location:32 → 279

SSH-N; N-terminal domain conserved in slingshot (SSH) phosphatases

pfam08766
Location:298 → 349

DEK_C; DEK C terminal domain

cl28904
Location:352 → 435

PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily