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    PLAA phospholipase A2 activating protein [ Homo sapiens (human) ]

    Gene ID: 9373, updated on 4-Jan-2025

    Summary

    Official Symbol
    PLAAprovided by HGNC
    Official Full Name
    phospholipase A2 activating proteinprovided by HGNC
    Primary source
    HGNC:HGNC:9043
    See related
    Ensembl:ENSG00000137055 MIM:603873; AllianceGenome:HGNC:9043
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DOA1; PLAP; PLA2P; NDMSBA
    Summary
    Predicted to enable ubiquitin binding activity. Involved in cellular response to lipopolysaccharide; macroautophagy; and positive regulation of phospholipase A2 activity. Located in cytoplasm; extracellular exosome; and nucleus. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in testis (RPKM 6.9), bone marrow (RPKM 5.3) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See PLAA in Genome Data Viewer
    Location:
    9p21.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (26903372..26947242, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (26913987..26957845, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (26903370..26947240, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene caspase activity and apoptosis inhibitor 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:26892199-26892778 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:26892779-26893358 Neighboring gene H3 histone pseudogene 31 Neighboring gene RNA, 7SL, cytoplasmic 100, pseudogene Neighboring gene MPRA-validated peak7213 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:26936699-26937379 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:26946315-26946990 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:26946991-26947664 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:26955622-26956357 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr9:26956358-26957092 Neighboring gene Sharpr-MPRA regulatory region 4046 Neighboring gene IFT74 antisense RNA 1 Neighboring gene intraflagellar transport 74 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:26975626-26976196 Neighboring gene leucine rich repeat containing 19

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (30 hits/1265 screens)

    Associated conditions

    EBI GWAS Catalog

    Description
    Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.
    EBI GWAS Catalog

    Interactions

    General gene information

    Clone Names

    • FLJ11281, FLJ12699

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phospholipase A2 activator activity  
    enables protein binding PubMed 
    enables ubiquitin binding  
    Process Evidence Code Pubs
    involved_in cellular response to lipopolysaccharide PubMed 
    involved_in inflammatory response  
    involved_in macroautophagy PubMed 
    involved_in negative regulation of protein K63-linked ubiquitination  
    involved_in nervous system development  
    involved_in phospholipid metabolic process PubMed 
    involved_in positive regulation of dendrite extension  
    involved_in positive regulation of neuron migration  
    involved_in positive regulation of phospholipase A2 activity PubMed 
    involved_in positive regulation of synaptic vesicle recycling  
    involved_in prostaglandin metabolic process  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process  
    involved_in signal transduction PubMed 
    involved_in ubiquitin recycling  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in extracellular exosome PubMed 
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in synapse  

    General protein information

    Preferred Names
    phospholipase A-2-activating protein
    Names
    DOA1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031689.3 → NP_001026859.1  phospholipase A-2-activating protein isoform 1

      See identical proteins and their annotated locations for NP_001026859.1

      Status: VALIDATED

      Source sequence(s)
      AL356133, BC032551, DA591576
      Consensus CDS
      CCDS35000.1
      UniProtKB/Swiss-Prot
      Q53EU5, Q5VY33, Q9NUL8, Q9NVE9, Q9UF53, Q9Y263, Q9Y5L1
      Related
      ENSP00000380460.3, ENST00000397292.8
      Conserved Domains (6) summary
      COG2319
      Location:6 → 296
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:10 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05831
      Location:298 → 352
      GAGE; GAGE protein
      pfam08324
      Location:536 → 789
      PUL; PUL domain
      pfam09070
      Location:346 → 458
      PFU; PFU (PLAA family ubiquitin binding)
      sd00039
      Location:26 → 63
      7WD40; WD40 repeat [structural motif]
    2. NM_001321546.2 → NP_001308475.1  phospholipase A-2-activating protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL356133
      Conserved Domains (6) summary
      COG2319
      Location:6 → 296
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:10 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05831
      Location:298 → 352
      GAGE; GAGE protein
      pfam08324
      Location:513 → 766
      PUL; PUL domain
      pfam09070
      Location:346 → 458
      PFU; PFU (PLAA family ubiquitin binding)
      sd00039
      Location:26 → 63
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      26903372..26947242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424083.1 → XP_047280039.1  phospholipase A-2-activating protein isoform X1

      Related
      ENSP00000429372.1, ENST00000520884.5
    2. XM_011518072.4 → XP_011516374.1  phospholipase A-2-activating protein isoform X3

      UniProtKB/TrEMBL
      E5RIM3
      Conserved Domains (5) summary
      COG2319
      Location:6 → 296
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:10 → 297
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05831
      Location:298 → 352
      GAGE; GAGE protein
      pfam09070
      Location:346 → 458
      PFU; PFU (PLAA family ubiquitin binding)
      sd00039
      Location:69 → 110
      7WD40; WD40 repeat [structural motif]
    3. XM_017015319.3 → XP_016870808.1  phospholipase A-2-activating protein isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      26913987..26957845 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364180.1 → XP_054220155.1  phospholipase A-2-activating protein isoform X1

    2. XM_054364181.1 → XP_054220156.1  phospholipase A-2-activating protein isoform X2

    3. XM_054364182.1 → XP_054220157.1  phospholipase A-2-activating protein isoform X3

      UniProtKB/TrEMBL
      E5RIM3

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