U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    CAPNS2 calpain small subunit 2 [ Homo sapiens (human) ]

    Gene ID: 84290, updated on 4-Jan-2025

    Summary

    Official Symbol
    CAPNS2provided by HGNC
    Official Full Name
    calpain small subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:16371
    See related
    Ensembl:ENSG00000256812 MIM:616767; AllianceGenome:HGNC:16371
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSS2
    Summary
    Enables calcium-dependent cysteine-type endopeptidase activity. Predicted to be located in cytosol and plasma membrane. Predicted to be part of calpain complex. [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See CAPNS2 in Genome Data Viewer
    Location:
    16q12.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (55566684..55567687)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (61364815..61365818)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (55600596..55601599)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MMP2 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:55503673-55504564 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:55504565-55505455 Neighboring gene NANOG hESC enhancer GRCh37_chr16:55508340-55508859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:55536405-55536906 Neighboring gene matrix metallopeptidase 2 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:55633008-55633567 Neighboring gene Sharpr-MPRA regulatory region 3138 Neighboring gene uncharacterized LOC124903693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:55690152-55690687 Neighboring gene solute carrier family 6 member 2 Neighboring gene uncharacterized LOC105371280

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (8 hits/1259 screens)

    EBI GWAS Catalog

    Description
    A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC12536, MGC14804

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    part_of calpain complex  
    located_in cytosol  
    located_in plasma membrane  

    General protein information

    Preferred Names
    calpain small subunit 2
    Names
    calcium-dependent protease small subunit 2
    NP_115706.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032330.3NP_115706.1  calpain small subunit 2

      Status: VALIDATED

      Source sequence(s)
      BC005397, BC006000
      Consensus CDS
      CCDS54010.1
      UniProtKB/Swiss-Prot
      Q96L46, Q9BPV4
      Related
      ENSP00000400882.2, ENST00000457326.3
      Conserved Domains (1) summary
      cd16188
      Location:80248
      EFh_PEF_CPNS1_2; Penta-EF hand, calcium binding motifs, found in calcium-dependent protease small subunit CAPNS1 and CAPNS2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      55566684..55567687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      61364815..61365818
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Loading
    Loading
    External link. Please review our privacy policy.