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    NUP35 nucleoporin 35 [ Homo sapiens (human) ]

    Gene ID: 129401, updated on 4-Jan-2025

    Summary

    Official Symbol
    NUP35provided by HGNC
    Official Full Name
    nucleoporin 35provided by HGNC
    Primary source
    HGNC:HGNC:29797
    See related
    Ensembl:ENSG00000163002 MIM:608140; AllianceGenome:HGNC:29797
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MP44; NP44; MP-44; NUP53
    Summary
    This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013]
    Expression
    Ubiquitous expression in testis (RPKM 6.9), adrenal (RPKM 3.5) and 25 other tissues See more
    Orthologs
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    Genomic context

    See NUP35 in Genome Data Viewer
    Location:
    2q32.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (183117514..183161680)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (183606527..183650714)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (183982242..184026408)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr2:183935853-183936421 Neighboring gene keratin 8 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16838 Neighboring gene dual specificity phosphatase 19 Neighboring gene uncharacterized LOC124907917 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:183989221-183989989 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:184037030-184037616 Neighboring gene uncharacterized LOC124906103 Neighboring gene LIN28A pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding  
    enables nucleic acid binding  
    enables phospholipid binding  
    enables protein binding PubMed 
    enables structural constituent of nuclear pore  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus  
    involved_in cellular response to leukemia inhibitory factor  
    involved_in mRNA transport  
    involved_in nuclear pore organization  
    involved_in nucleocytoplasmic transport PubMed 
    Component Evidence Code Pubs
    located_in cytosol  
    located_in nuclear envelope PubMed 
    located_in nuclear envelope  
    located_in nuclear membrane  
    part_of nuclear pore PubMed 
    part_of nuclear pore central transport channel  
    part_of nuclear pore nuclear basket  
    located_in nucleoplasm  
    located_in plasma membrane  

    General protein information

    Preferred Names
    nucleoporin NUP35
    Names
    mitotic phosphoprotein 44
    nuclear pore complex protein Nup53
    nucleoporin 35kDa
    nucleoporin NUP53

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287584.2 → NP_001274513.1  nucleoporin NUP35 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC064871, AK302350, BC035597
      Consensus CDS
      CCDS74614.1
      UniProtKB/TrEMBL
      A8K3Z5
      Related
      ENSP00000387305.1, ENST00000409798.5
      Conserved Domains (1) summary
      cd12722
      Location:155 → 228
      RRM_Nup53; RNA recognition motif in nucleoporin Nup53
    2. NM_001287585.2 → NP_001274514.1  nucleoporin NUP35 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (c) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AK298199, BC061698, BI818393, CX787176, FN117342
      UniProtKB/Swiss-Prot
      Q8NFH5
      Conserved Domains (1) summary
      cd12722
      Location:54 → 127
      RRM_Nup53; RNA recognition motif (RRM) found in nucleoporin Nup53
    3. NM_138285.5 → NP_612142.2  nucleoporin NUP35 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC061698, FN117342
      Consensus CDS
      CCDS2290.1
      UniProtKB/Swiss-Prot
      B4DP57, B4DYB4, Q4ZFZ9, Q53S95, Q8NFH5, Q8TDJ1
      UniProtKB/TrEMBL
      A8K3Z5
      Related
      ENSP00000295119.4, ENST00000295119.9
      Conserved Domains (1) summary
      cd12722
      Location:172 → 245
      RRM_Nup53; RNA recognition motif (RRM) found in nucleoporin Nup53

    RNA

    1. NR_109856.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK289601, BC035597

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      183117514..183161680
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510577.3 → XP_011508879.1  nucleoporin NUP35 isoform X2

      UniProtKB/TrEMBL
      A8K3Z5
      Conserved Domains (1) summary
      cd12722
      Location:155 → 228
      RRM_Nup53; RNA recognition motif in nucleoporin Nup53
    2. XM_011510576.4 → XP_011508878.1  nucleoporin NUP35 isoform X2

      UniProtKB/TrEMBL
      A8K3Z5
      Conserved Domains (1) summary
      cd12722
      Location:155 → 228
      RRM_Nup53; RNA recognition motif in nucleoporin Nup53
    3. XM_047443270.1 → XP_047299226.1  nucleoporin NUP35 isoform X2

      UniProtKB/TrEMBL
      A8K3Z5
    4. XM_006712254.4 → XP_006712317.1  nucleoporin NUP35 isoform X2

      UniProtKB/TrEMBL
      A8K3Z5
      Conserved Domains (1) summary
      cd12722
      Location:155 → 228
      RRM_Nup53; RNA recognition motif in nucleoporin Nup53
    5. XM_017003308.1 → XP_016858797.1  nucleoporin NUP35 isoform X1

      UniProtKB/TrEMBL
      A8K3Z5
      Conserved Domains (1) summary
      cd12722
      Location:175 → 248
      RRM_Nup53; RNA recognition motif in nucleoporin Nup53

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      183606527..183650714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340472.1 → XP_054196447.1  nucleoporin NUP35 isoform X2

      UniProtKB/TrEMBL
      A8K3Z5
    2. XM_054340471.1 → XP_054196446.1  nucleoporin NUP35 isoform X1

      UniProtKB/TrEMBL
      A8K3Z5

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