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    Tmc6 transmembrane channel like 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 688280, updated on 27-Dec-2024

    Summary

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    Symbol
    Tmc6provided by RGD
    Full Name
    transmembrane channel like 6provided by RGD
    Primary source
    RGD:1591146
    See related
    EnsemblRapid:ENSRNOG00000053469 AllianceGenome:RGD:1591146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AABR07030861.1
    Summary
    Predicted to enable mechanosensitive monoatomic ion channel activity. Predicted to be involved in intracellular zinc ion homeostasis and protein stabilization. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nuclear membrane. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human TMC6 (transmembrane channel like 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 88.6), Thymus (RPKM 86.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tmc6 in Genome Data Viewer
    Location:
    10q32.2
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (103480762..103498207, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (102982059..102999509, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (106766857..106783004, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100912319 Neighboring gene trinucleotide repeat containing adaptor 6C Neighboring gene smilar to human chromosome 17 open reading frame 99 Neighboring gene U6 spliceosomal RNA Neighboring gene transmembrane channel-like 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutations in two adjacent novel genes are associated with epidermodysplasia verruciformis. Ramoz N, et al. Nat Genet, 2002 Dec. PMID 12426567
    2. Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses. Lazarczyk M, et al. J Exp Med, 2008 Jan 21. PMID 18158319, Free PMC Article
    3. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane channel-like protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398946.2 → NP_001385875.1  transmembrane channel-like protein 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A0G2JT44
      Conserved Domains (1) summary
      pfam07810
      Location:542 → 648
      TMC; TMC domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      103480762..103498207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087493.2 → XP_038943421.1  transmembrane channel-like protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT44
      Conserved Domains (1) summary
      pfam07810
      Location:542 → 648
      TMC; TMC domain

    2. XM_039087499.2 → XP_038943427.1  transmembrane channel-like protein 6 isoform X6

      Conserved Domains (1) summary
      pfam07810
      Location:542 → 631
      TMC; TMC domain

    3. XM_063269863.1 → XP_063125933.1  transmembrane channel-like protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JT44, A0A8I6AQ94, A6HL23
      Related
      ENSRNOP00000096105.1, ENSRNOT00000114668.2

    4. XM_039087494.2 → XP_038943422.1  transmembrane channel-like protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JT44, A0A8I6AQ94, A6HL23
      Conserved Domains (1) summary
      pfam07810
      Location:541 → 647
      TMC; TMC domain

    5. XM_039087490.2 → XP_038943418.1  transmembrane channel-like protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT44
      Conserved Domains (1) summary
      pfam07810
      Location:542 → 648
      TMC; TMC domain

    6. XM_039087492.2 → XP_038943420.1  transmembrane channel-like protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT44
      Conserved Domains (1) summary
      pfam07810
      Location:542 → 648
      TMC; TMC domain

    7. XM_039087491.2 → XP_038943419.1  transmembrane channel-like protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JT44
      Conserved Domains (1) summary
      pfam07810
      Location:542 → 648
      TMC; TMC domain

    8. XM_039087496.2 → XP_038943424.1  transmembrane channel-like protein 6 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JT44
      Conserved Domains (1) summary
      pfam07810
      Location:457 → 563
      TMC; TMC domain

    9. XM_039087497.2 → XP_038943425.1  transmembrane channel-like protein 6 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JT44
      Conserved Domains (1) summary
      pfam07810
      Location:399 → 505
      TMC; TMC domain

    10. XM_039087500.2 → XP_038943428.1  transmembrane channel-like protein 6 isoform X7

      Conserved Domains (1) summary
      pfam07810
      Location:378 → 484
      TMC; TMC domain

    11. XM_039087495.2 → XP_038943423.1  transmembrane channel-like protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JT44
      Related
      ENSRNOP00000068563.3, ENSRNOT00000077495.3
      Conserved Domains (1) summary
      pfam07810
      Location:542 → 648
      TMC; TMC domain

    RNA

    1. XR_005490571.2 RNA Sequence

    2. XR_005490574.2 RNA Sequence

    3. XR_005490568.2 RNA Sequence

    4. XR_005490570.2 RNA Sequence

    5. XR_005490573.2 RNA Sequence

    6. XR_010055253.1 RNA Sequence

    7. XR_005490575.2 RNA Sequence

    8. XR_005490572.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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