MIR1284 microRNA 1284 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MIR1284provided by HGNC
Official Full Name: microRNA 1284provided by HGNC
Primary source: HGNC:HGNC:35362
See related: Ensembl:ENSG00000221264 miRBase:MI0006431; AllianceGenome:HGNC:35362
Gene type: ncRNA
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MIRN1284; mir-1284; hsa-mir-1284
Summary: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Genomic context

Location:: 3p13

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (71541970..71542089, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (71581244..71581363, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (71591121..71591240, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-1284 suppresses the proliferation and migration of thyroid cancer.
Title: MiR-1284 suppresses the proliferation and migration of thyroid cancer.
The overexpression of miR-1284 inhibited the cell proliferation and migration, and altered the protein expression of epithelial-mesenchymal transition (EMT)-associated genes (E-cadherin, N-cadherin, Vimentin, and Snail), which was reversed by HMGB1 overexpression. In conclusion, miR-1284 can function as a new regulator to inhibit osteosarcoma cell proliferation and migration by targeting HMGB1.
Title: miRNA-1284, a regulator of HMGB1, inhibits cell proliferation and migration in osteosarcoma.
miR-1284 suppressed the proliferation, migration, and invasion of breast cancer cells via targeting ZIC2.
Title: miR-1284 Inhibits the Growth and Invasion of Breast Cancer Cells by Targeting ZIC2.
miR-1284 enhances sensitivity of cervical cancer cells to cisplatin via targeting HMGB1; patients with low level of miR-1284 had low overall survival rate
Title: MiR-1284 enhances sensitivity of cervical cancer cells to cisplatin via downregulating HMGB1.
miR1284 affects cell proliferation and apoptosis of lung cancer cells.
Title: miRNA‑1284 inhibits cell growth and induces apoptosis of lung cancer cells.
miR-1284 can function as a new regulator to reduce gastric cancer multidrug resistant cells by targeting EIF4A1.
Title: MiR-1284 modulates multidrug resistance of gastric cancer cells by targeting EIF4A1.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.