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    Ankrd50 ankyrin repeat domain containing 50 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294988, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Ankrd50provided by RGD
    Official Full Name
    ankyrin repeat domain containing 50provided by RGD
    Primary source
    RGD:1311665
    See related
    EnsemblRapid:ENSRNOG00000010534 AllianceGenome:RGD:1311665
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311665
    Summary
    Predicted to be involved in endocytic recycling. Orthologous to human ANKRD50 (ankyrin repeat domain containing 50). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 174.9), Heart (RPKM 122.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankrd50 in Genome Data Viewer
    Location:
    2q25
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (123394311..123428788, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (121466275..121500758, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (125289071..125323527, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6, pseudogene 3 Neighboring gene ribosomal protein L23A like 3 Neighboring gene uncharacterized LOC103691533 Neighboring gene uncharacterized LOC120100576

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling. McGough IJ, et al. J Cell Sci, 2014 Nov 15. PMID 25278552, Free PMC Article
    2. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in endocytic recycling ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat domain-containing protein 50
    Names
    ankrin repeat domain 50
    ankyrin repeat domain 50

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191606.1 → NP_001178535.1  ankyrin repeat domain-containing protein 50

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      F1LWB9
      Related
      ENSRNOP00000043031.4, ENSRNOT00000045837.7
      Conserved Domains (4) summary
      PHA02876
      Location:763 → 1102
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:625 → 907
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:676 → 707
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:23 → 195
      AAA_16; AAA ATPase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      123394311..123428788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760922.4 → XP_008759144.1  ankyrin repeat domain-containing protein 50 isoform X1

      UniProtKB/TrEMBL
      F1LWB9
      Conserved Domains (4) summary
      PHA02876
      Location:763 → 1102
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:625 → 907
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:676 → 707
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:23 → 195
      AAA_16; AAA ATPase domain

    2. XM_008760921.4 → XP_008759143.1  ankyrin repeat domain-containing protein 50 isoform X1

      UniProtKB/TrEMBL
      F1LWB9
      Conserved Domains (4) summary
      PHA02876
      Location:763 → 1102
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:625 → 907
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:676 → 707
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:23 → 195
      AAA_16; AAA ATPase domain

    3. XM_008760920.4 → XP_008759142.1  ankyrin repeat domain-containing protein 50 isoform X1

      UniProtKB/TrEMBL
      F1LWB9
      Conserved Domains (4) summary
      PHA02876
      Location:763 → 1102
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:625 → 907
      PHA03095; ankyrin-like protein; Provisional
      sd00045
      Location:676 → 707
      ANK; ANK repeat [structural motif]
      pfam13191
      Location:23 → 195
      AAA_16; AAA ATPase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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