METTL3 methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit [Homo sapiens (human)] - Gene

Summary

Official Symbol: METTL3provided by HGNC
Official Full Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunitprovided by HGNC
Primary source: HGNC:HGNC:17563
See related: Ensembl:ENSG00000165819 MIM:612472; AllianceGenome:HGNC:17563
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: M6A; IME4; Spo8; MT-A70; hMETTL3
Summary: This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lymph node (RPKM 23.5), testis (RPKM 22.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q11.2

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (21498138..21511340, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (15695502..15708704, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (21966282..21979482, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

METTL3-mediated TIM1 promotes macrophage M1 polarization and inflammation through IGF2BP2-dependent manner.
Title: METTL3-mediated TIM1 promotes macrophage M1 polarization and inflammation through IGF2BP2-dependent manner.
METTL3-driven m6A modification of lncRNA FAM230B suppresses ferroptosis by modulating miR-27a-5p/BTF3 axis in gastric cancer.
Title: METTL3-driven m6A modification of lncRNA FAM230B suppresses ferroptosis by modulating miR-27a-5p/BTF3 axis in gastric cancer.
The indispensability of methyltransferase-like 3 in the immune system: from maintaining homeostasis to driving function.
Title: The indispensability of methyltransferase-like 3 in the immune system: from maintaining homeostasis to driving function.
METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1.
Title: METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1.
METTL3/IGF2BP1 influences the development of non-small-cell lung cancer by mediating m6A methylation modification of TRPV1.
Title: METTL3/IGF2BP1 influences the development of non-small-cell lung cancer by mediating m6A methylation modification of TRPV1.
A novel interaction between RNA m[6]A methyltransferase METTL3 and RREB1.
Title: A novel interaction between RNA m(6)A methyltransferase METTL3 and RREB1.
METTL3 and IGF2BP1-Mediated m6A Modification of ZHX2 Promotes Tumor Property of Renal Cell Carcinoma.
Title: METTL3 and IGF2BP1-Mediated m6A Modification of ZHX2 Promotes Tumor Property of Renal Cell Carcinoma.
METTL3 Regulates the Translation of Oncogene Myc through m[6]A Modification and Promotes the Occurrence and Development of Cervical Cancer.
Title: METTL3 Regulates the Translation of Oncogene Myc through m(6)A Modification and Promotes the Occurrence and Development of Cervical Cancer.
METTL3's role in cervical cancer development through m[6]A modification.
Title: METTL3's role in cervical cancer development through m(6)A modification.
METTL3-STAT5B interaction facilitates the co-transcriptional m[6]A modification of mRNA to promote breast tumorigenesis.
Title: METTL3-STAT5B interaction facilitates the co-transcriptional m(6)A modification of mRNA to promote breast tumorigenesis.

Submit: New GeneRIF Correction See all GeneRIFs (356)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH44762 (e-PCR)
- UniSTS:32768

SHGC-64027 (e-PCR)
- UniSTS:31045

SHGC-36315 (e-PCR)
- UniSTS:873

D15S1477 (e-PCR)
- UniSTS:474482

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables S-adenosyl-L-methionine binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA m(6)A methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA m(6)A methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA m(6)A methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IDA Inferred from Direct Assay more info	PubMed
involved_in RNA methylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to UV	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in dosage compensation by inactivation of X chromosome	IDA Inferred from Direct Assay more info	PubMed
involved_in endothelial to hematopoietic transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in forebrain radial glial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in gliogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in mRNA destabilization	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in mRNA modification	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of type I interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cap-independent translational initiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in primary miRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of hematopoietic stem cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of meiotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info
part_of RNA N6-methyladenosine methyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA N6-methyladenosine methyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of RNA N6-methyladenosine methyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RNA N6-methyladenosine methyltransferase complex	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nuclear body	IDA Inferred from Direct Assay more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
part_of oxidoreductase complex	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: N(6)-adenosine-methyltransferase catalytic subunit METTL3; N6-adenosine-methyltransferase catalytic subunit

Names: N(6)-adenosine-methyltransferase 70 kDa subunit; N6-adenosine-methyltransferase 70 kDa subunit; adoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase; mRNA (2'-O-methyladenosine-N(6)-)-methyltransferase; mRNA m(6)A methyltransferase; methyltransferase like 3; methyltransferase-like protein 3

NP_062826.2

EC 2.1.1.348

XP_006720269.1

EC 2.1.1.348

XP_011535270.1

EC 2.1.1.348

XP_047287550.1

EC 2.1.1.348

XP_054232378.1

EC 2.1.1.348

XP_054232379.1

EC 2.1.1.348

XP_054232380.1

EC 2.1.1.348

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019852.5 → NP_062826.2 N(6)-adenosine-methyltransferase catalytic subunit METTL3

See identical proteins and their annotated locations for NP_062826.2

Status: REVIEWED

Source sequence(s)

AL161747, BC001650, CA311761, DC295053

Consensus CDS

CCDS32044.1

UniProtKB/Swiss-Prot

O14736, Q86U44, Q86V05, Q9HB32

Related

ENSP00000298717.3, ENST00000298717.9

Conserved Domains (1) summary

pfam05063
Location:389 → 550

MT-A70

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000014.9 Reference GRCh38.p14 Primary Assembly

Range

21498138..21511340 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011536968.3 → XP_011535270.1 N6-adenosine-methyltransferase catalytic subunit isoform X1

Conserved Domains (1) summary

cl01947
Location:389 → 528

MT-A70; MT-A70
XM_006720206.5 → XP_006720269.1 N6-adenosine-methyltransferase catalytic subunit isoform X3

Conserved Domains (1) summary

pfam05063
Location:105 → 266

MT-A70
XM_047431594.1 → XP_047287550.1 N6-adenosine-methyltransferase catalytic subunit isoform X2

UniProtKB/TrEMBL

B4E2F6

Related

ENSP00000445523.1, ENST00000543235.5

Alternate T2T-CHM13v2.0

Genomic

NC_060938.1 Alternate T2T-CHM13v2.0

Range

15695502..15708704 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054376403.1 → XP_054232378.1 N6-adenosine-methyltransferase catalytic subunit isoform X1
XM_054376405.1 → XP_054232380.1 N6-adenosine-methyltransferase catalytic subunit isoform X3
XM_054376404.1 → XP_054232379.1 N6-adenosine-methyltransferase catalytic subunit isoform X2

UniProtKB/TrEMBL

B4E2F6