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    Cep78 centrosomal protein 78 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 60347, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cep78provided by RGD
    Official Full Name
    centrosomal protein 78provided by RGD
    Primary source
    RGD:620464
    See related
    EnsemblRapid:ENSRNOG00000014041 AllianceGenome:RGD:620464
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ip63
    Summary
    Predicted to be involved in several processes, including flagellated sperm motility; negative regulation of protein ubiquitination; and protein localization to centrosome. Predicted to be active in centriole; centrosome; and ciliary basal body. Orthologous to human CEP78 (centrosomal protein 78). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 44.6), Thymus (RPKM 41.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cep78 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (222674193..222702124, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (213246183..213275275, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (233185815..233214876, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene phosphoserine aminotransferase 1 Neighboring gene uncharacterized LOC102553402 Neighboring gene uncharacterized LOC134485208 Neighboring gene G protein subunit alpha q

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in CEP78 Cause Cone-Rod Dystrophy and Hearing Loss Associated with Primary-Cilia Defects. Nikopoulos K, et al. Am J Hum Genet, 2016 Sep 1. PMID 27588451, Free PMC Article
    2. Cep78 is a new centriolar protein involved in Plk4-induced centriole overduplication. Brunk K, et al. J Cell Sci, 2016 Jul 15. PMID 27246242
    3. The novel testicular enrichment protein Cfap58 is required for Notch-associated ciliogenesis. Li ZZ, et al. Biosci Rep, 2020 Jan 31. PMID 31904090, Free PMC Article
    4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 78 kDa
    Names
    centrosomal protein 78kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021741.2 → NP_068509.2  centrosomal protein of 78 kDa

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001, X99330
      UniProtKB/TrEMBL
      A6I0H6, F1LP29
      Related
      ENSRNOP00000018951.5, ENSRNOT00000018951.8
      Conserved Domains (2) summary
      cd00116
      Location:113 → 299
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cl09820
      Location:413 → 485
      PhaP_Bmeg; Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      222674193..222702124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231136.5 → XP_006231198.1  centrosomal protein of 78 kDa isoform X1

      See identical proteins and their annotated locations for XP_006231198.1

      UniProtKB/TrEMBL
      A6I0H6, A6I0H7
      Conserved Domains (2) summary
      cd00116
      Location:113 → 299
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cl09820
      Location:413 → 485
      PhaP_Bmeg; Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg)

    2. XM_063272456.1 → XP_063128526.1  centrosomal protein of 78 kDa isoform X6

    3. XM_039088989.2 → XP_038944917.1  centrosomal protein of 78 kDa isoform X2

      UniProtKB/TrEMBL
      A6I0H6
      Conserved Domains (1) summary
      cl39015
      Location:23 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    4. XM_039088994.2 → XP_038944922.1  centrosomal protein of 78 kDa isoform X5

      Conserved Domains (1) summary
      cl39015
      Location:113 → 299
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    5. XM_039088993.2 → XP_038944921.1  centrosomal protein of 78 kDa isoform X4

      Conserved Domains (1) summary
      cl39015
      Location:113 → 299
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

    6. XM_039088991.2 → XP_038944919.1  centrosomal protein of 78 kDa isoform X3

      UniProtKB/TrEMBL
      A6I0H6
      Conserved Domains (1) summary
      cl39015
      Location:23 → 217
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    Nucleotide Protein Strain
    Heading Accession and Version

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