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    Vmac vimentin-type intermediate filament associated coiled-coil protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363327, updated on 9-Dec-2024

    Summary

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    Symbol
    Vmacprovided by RGD
    Full Name
    vimentin-type intermediate filament associated coiled-coil proteinprovided by RGD
    Primary source
    RGD:1303340
    See related
    EnsemblRapid:ENSRNOG00000065863 AllianceGenome:RGD:1303340
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Located in type III intermediate filament. Orthologous to human VMAC (vimentin type intermediate filament associated coiled-coil protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 141.3), Adrenal (RPKM 86.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vmac in Genome Data Viewer
    Location:
    9q11
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (1633874..1637538, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (1546747..1550417, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (10338260..10341903)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene lon peptidase 1, mitochondrial Neighboring gene cation channel sperm associated auxiliary subunit delta Neighboring gene RAN binding protein 3 Neighboring gene calcyphosine Neighboring gene NADH:ubiquinone oxidoreductase subunit A11 Neighboring gene fucosyltransferase 4, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Vmac: a novel protein associated with vimentin-type intermediate filament in podocytes of rat kidney. Yamamoto Y, et al. Biochem Biophys Res Commun, 2004 Mar 19. PMID 14985129
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in type III intermediate filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in type III intermediate filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    vimentin-type intermediate filament-associated coiled-coil protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001720.2 → NP_001001720.1  vimentin-type intermediate filament-associated coiled-coil protein

      See identical proteins and their annotated locations for NP_001001720.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      Q6QZQ4
      UniProtKB/TrEMBL
      A6KQV3
      Conserved Domains (1) summary
      pfam15272
      Location:35 → 113
      BBP1_C; Spindle pole body component BBP1, C-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      1633874..1637538 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766765.4 → XP_008764987.3  vimentin-type intermediate filament-associated coiled-coil protein isoform X1

      Related
      ENSRNOP00000096954.2, ENSRNOT00000109435.2
      Conserved Domains (1) summary
      TIGR02168
      Location:40 → 158
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_008766766.3 → XP_008764988.1  vimentin-type intermediate filament-associated coiled-coil protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6ARR3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6QZQ4.1 GenPept UniProtKB/Swiss-Prot:Q6QZQ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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