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    Ldah lipid droplet associated hydrolase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313949, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ldahprovided by RGD
    Official Full Name
    lipid droplet associated hydrolaseprovided by RGD
    Primary source
    RGD:1311648
    See related
    EnsemblRapid:ENSRNOG00000021475 AllianceGenome:RGD:1311648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311648
    Summary
    Predicted to enable sterol ester esterase activity. Predicted to be involved in cholesterol homeostasis; intracellular triglyceride homeostasis; and lipid storage. Predicted to act upstream of with a positive effect on lipid droplet fusion. Predicted to be located in endoplasmic reticulum. Predicted to be active in lipid droplet. Orthologous to human LDAH (lipid droplet associated hydrolase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 93.0), Adrenal (RPKM 75.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ldah in Genome Data Viewer
    Location:
    6q14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (36801359..36885929)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (31082045..31166625)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (33407223..33491726)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene cyclin F, pseudogene 2 Neighboring gene uncharacterized LOC103692595 Neighboring gene growth differentiation factor 7 Neighboring gene uncharacterized LOC134479336 Neighboring gene HCLS1 binding protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Novel lipid droplet-associated serine hydrolase regulates macrophage cholesterol mobilization. Goo YH, et al. Arterioscler Thromb Vasc Biol, 2014 Feb. PMID 24357060, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol ester esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sterol ester esterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in intracellular triglyceride homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular triglyceride homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_positive_effect lipid droplet fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid droplet fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect lipid droplet fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid droplet fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid storage IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid storage IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lipid droplet ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    lipid droplet-associated hydrolase
    Names
    UPF0554 protein C2orf43 homolog
    lipid droplet-associated serine hydrolase
    NP_001014097.1
    NP_001381198.1
    XP_063117952.1
    XP_063117953.1
    XP_063117954.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014075.2 → NP_001014097.1  lipid droplet-associated hydrolase

      See identical proteins and their annotated locations for NP_001014097.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q5HZX7
      UniProtKB/TrEMBL
      A0A8L2QK08
      Conserved Domains (1) summary
      pfam10230
      Location:43 → 303
      LIDHydrolase; Lipid-droplet associated hydrolase

    2. NM_001394269.1 → NP_001381198.1  lipid droplet-associated hydrolase

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q5HZX7
      UniProtKB/TrEMBL
      A0A8L2QK08
      Related
      ENSRNOP00000033708.6, ENSRNOT00000030244.8
      Conserved Domains (1) summary
      pfam10230
      Location:43 → 303
      LIDHydrolase; Lipid-droplet associated hydrolase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      36801359..36885929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261883.1 → XP_063117953.1  lipid droplet-associated hydrolase isoform X2

      UniProtKB/TrEMBL
      A0A8I6ABK2
      Related
      ENSRNOP00000089371.1, ENSRNOT00000096109.2

    2. XM_063261884.1 → XP_063117954.1  lipid droplet-associated hydrolase isoform X3

    3. XM_063261882.1 → XP_063117952.1  lipid droplet-associated hydrolase isoform X1

      UniProtKB/Swiss-Prot
      Q5HZX7
      UniProtKB/TrEMBL
      A0A8L2QK08

    RNA

    1. XR_010052083.1 RNA Sequence

    2. XR_010052084.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5HZX7.1 GenPept UniProtKB/Swiss-Prot:Q5HZX7

    Gene LinkOut

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