Ctnnd2 catenin delta 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctnnd2provided by RGD
Official Full Name: catenin delta 2provided by RGD
Primary source: RGD:620734
See related: EnsemblRapid:ENSRNOG00000010649 AllianceGenome:RGD:620734
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: A structural constituent of postsynaptic density. Involved in neuron projection retraction; positive regulation of axon extension; and regulation of postsynaptic membrane neurotransmitter receptor levels. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in anxiety disorder; major depressive disorder; and schizophrenia. Orthologous to human CTNND2 (catenin delta 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 119.0) and Thymus (RPKM 8.0) See more
Orthologs: human mouse all
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Genomic context

Location:: 2q22-q23

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (82879469..83727409)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (81168525..82016495)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (83227247..84094315)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

delta-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions.
Title: δ-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions.
delta-catenin is potentially involved in facilitating the interaction, ubiquitination, and subsequent turnover of beta-catenin in neuronal cells
Title: Delta-catenin/NPRAP: A new member of the glycogen synthase kinase-3beta signaling complex that promotes beta-catenin turnover in neurons.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D2Got41 (e-PCR)
- UniSTS:113423

D2Rat211 (e-PCR), detects polymorphism
- UniSTS:227367

D2Rat212 (e-PCR), detects polymorphism
- UniSTS:227368

AU049514 (e-PCR)
- UniSTS:145961

BE101962 (e-PCR)
- UniSTS:243785

D2Rat275 (e-PCR), detects polymorphism
- UniSTS:227414

BE102128 (e-PCR)
- UniSTS:244073

D5S2317 (e-PCR)
- UniSTS:81271

D2Rat324 (e-PCR), detects polymorphism
- UniSTS:227458

BF386798 (e-PCR)
- UniSTS:243846

AU047732 (e-PCR)
- UniSTS:110218

D2Got33 (e-PCR)
- UniSTS:115344

RH128575 (e-PCR)
- UniSTS:211883

RH137492 (e-PCR)
- UniSTS:219580

BE120970 (e-PCR)
- UniSTS:247487

Ctnnd2 (e-PCR), detects polymorphism
- UniSTS:527300

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-catenin binding	IEA Inferred from Electronic Annotation more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in dendritic spine morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in dendritic spine morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within learning	ISO Inferred from Sequence Orthology more info
involved_in maintenance of postsynaptic density structure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within morphogenesis of a branching structure	ISO Inferred from Sequence Orthology more info
involved_in neuron projection retraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in synapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: catenin delta-2

Names: catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271502.2 → NP_001258431.2 catenin delta-2 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

F1M787

Related

ENSRNOP00000045121.5, ENSRNOT00000044871.6
NM_001415019.1 → NP_001401948.1 catenin delta-2 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I6AP92

Related

ENSRNOP00000096253.1, ENSRNOT00000119467.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

82879469..83727409

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101550.2 → XP_038957478.1 catenin delta-2 isoform X1

Conserved Domains (5) summary

smart00185
Location:502 → 542

ARM; Armadillo/beta-catenin-like repeats

PLN03200
Location:471 → 644

PLN03200; cellulose synthase-interactive protein; Provisional

PHA03247
Location:61 → 468

PHA03247; large tegument protein UL36; Provisional

sd00043
Location:473 → 498

ARM; armadillo repeat [structural motif]

pfam00514
Location:755 → 796

Arm; Armadillo/beta-catenin-like repeat