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    Lgi1 leucine-rich, glioma inactivated 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 252892, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lgi1provided by RGD
    Official Full Name
    leucine-rich, glioma inactivated 1provided by RGD
    Primary source
    RGD:628742
    See related
    EnsemblRapid:ENSRNOG00000014758 AllianceGenome:RGD:628742
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable signaling receptor binding activity. Involved in positive regulation of synaptic transmission. Located in axon initial segment; dendrite; and extracellular space. Used to study epilepsy and epilepsy with generalized tonic-clonic seizures. Human ortholog(s) of this gene implicated in familial temporal lobe epilepsy 1. Orthologous to human LGI1 (leucine rich glioma inactivated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 248.7), Muscle (RPKM 30.6) and 2 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lgi1 in Genome Data Viewer
    Location:
    1q53
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (245455691..245497036)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (236043269..236084617)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (256955944..256996835)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RGD1561251 Neighboring gene uncharacterized LOC134483993 Neighboring gene uncharacterized LOC120100027 Neighboring gene uncharacterized LOC134483994 Neighboring gene solute carrier family 35, member G1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Distribution of the epilepsy-related Lgi1 protein in rat cortical neurons. Malatesta M, et al. Histochem Cell Biol, 2009 Nov. PMID 19756693
    2. 5 alpha-pregnane-3 alpha, 21-diol-20-one (THDOC) attenuates mild stress-induced increases in plasma corticosterone via a non-glucocorticoid mechanism: comparison with alprazolam. Owens MJ, et al. Brain Res, 1992 Feb 28. PMID 1504771
    3. A rat model for LGI1-related epilepsies. Baulac S, et al. Hum Mol Genet, 2012 Aug 15. PMID 22589250
    4. Evaluation of seizure foci and genes in the Lgi1(L385R/+) mutant rat. Fumoto N, et al. Neurosci Res, 2014 Mar. PMID 24406746
    5. TLR4 activation inhibits the proliferation and osteogenic differentiation of skeletal muscle stem cells by downregulating LGI1. Tao H, et al. J Physiol Biochem, 2022 Aug. PMID 35294724

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission.
      Title: Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission.
    2. TLR4 activation inhibits the proliferation and osteogenic differentiation of skeletal muscle stem cells by downregulating LGI1.
      Title: TLR4 activation inhibits the proliferation and osteogenic differentiation of skeletal muscle stem cells by downregulating LGI1.
    3. ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment.
      Title: ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment.
    4. he down-regulation of Kir4.1 channels in astrocytes is involved in audiogenic epileptogenesis caused by Lgi1 mutation.
      Title: Down-Regulation of Astrocytic Kir4.1 Channels during the Audiogenic Epileptogenesis in Leucine-Rich Glioma-Inactivated 1 (Lgi1) Mutant Rats.
    5. These results of this study suggest that Lgi1(L385R/+) rats are useful as an animal model of human autosomal dominant lateral temporal lobe epilepsy.
      Title: Evaluation of seizure foci and genes in the Lgi1(L385R/+) mutant rat.
    6. The expression of LOTUS, LGI1, and ADAM22 in hippocampal subregions dissected from mature adult and aged rats cognitively phenotyped for spatial learning and memory by Morris water maze testing, was quantified.
      Title: Expression of NgR1-antagonizing proteins decreases with aging and cognitive decline in rat hippocampus.
    7. LGI1 epilepsy-causing missense mutations might cause a depletion of the protein in neurons, and not only a failure of Lgi1 secretion.
      Title: A rat model for LGI1-related epilepsies.
    8. The Lgi1 is a cytoplasmic protein distributed both in the soma and in the processes of neurons.
      Title: Distribution of the epilepsy-related Lgi1 protein in rat cortical neurons.
    9. ADAM22, a transmembrane protein that when mutated causes seizure, serves as a receptor for LGI1; LGI1 enhances AMPA receptor-mediated synaptic transmission in hippocampal slices; mutated form of LGI1 fails to bind to ADAM22
      Title: Epilepsy-related ligand/receptor complex LGI1 and ADAM22 regulate synaptic transmission.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105310

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    NOT enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of synaptic transmission IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in extracellular space NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic cleft ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich glioma-inactivated protein 1
    Names
    leucine-rich glioma-inactivated protein 1-like
    leucine-rich repeat LGI family, member 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145769.4 → NP_665712.1  leucine-rich glioma-inactivated protein 1 precursor

      See identical proteins and their annotated locations for NP_665712.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q5FWS7, Q8K4Y5
      UniProtKB/TrEMBL
      A0A8L2QA98, A6I186
      Related
      ENSRNOP00000078389.1, ENSRNOT00000113976.2
      Conserved Domains (4) summary
      TIGR00864
      Location:146 → 221
      PCC; polycystin cation channel protein
      sd00031
      Location:71 → 92
      LRR_1; leucine-rich repeat [structural motif]
      pfam03736
      Location:510 → 549
      EPTP; EPTP domain
      pfam13855
      Location:91 → 151
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      245455691..245497036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K4Y5.1 GenPept UniProtKB/Swiss-Prot:Q8K4Y5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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