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    Snx25 sorting nexin 25 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 306471, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Snx25provided by RGD
    Official Full Name
    sorting nexin 25provided by RGD
    Primary source
    RGD:1310150
    See related
    EnsemblRapid:ENSRNOG00000011116 AllianceGenome:RGD:1310150
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable phosphatidylinositol binding activity and type I transforming growth factor beta receptor binding activity. Predicted to be involved in negative regulation of transforming growth factor beta receptor signaling pathway and receptor catabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endosome. Orthologous to human SNX25 (sorting nexin 25). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 192.1), Brain (RPKM 153.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Snx25 in Genome Data Viewer
    Location:
    16q11
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (52867102..52971028)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (46134552..46238471)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (49328958..49432415)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482507 Neighboring gene solute carrier family 25 member 4 Neighboring gene cilia and flagella associated protein 97 Neighboring gene U6 spliceosomal RNA Neighboring gene Lrp2 binding protein Neighboring gene ankyrin repeat domain 37 Neighboring gene UFM1-specific peptidase 2 Neighboring gene cilia and flagella associated protein 96

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SNX25 regulates TGF-β signaling by enhancing the receptor degradation. Hao X, et al. Cell Signal, 2011 May. PMID 21266196
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type I transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sorting nexin-25

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432812.1 → NP_001419741.1  sorting nexin-25 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I5ZS17, F1M998

    2. NM_001432813.1 → NP_001419742.1  sorting nexin-25 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A6JPP4, F1M998

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      52867102..52971028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_224863.9 → XP_224863.6  sorting nexin-25 isoform X1

      Related
      ENSRNOP00000081215.1, ENSRNOT00000099611.2
      Conserved Domains (4) summary
      cd06878
      Location:648 → 770
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      pfam02194
      Location:148 → 303
      PXA; PXA domain
      pfam08628
      Location:847 → 953
      Nexin_C; Sorting nexin C terminal
      cl02565
      Location:437 → 545
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    2. XM_006253168.4 → XP_006253230.2  sorting nexin-25 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ABR0, F1M998
      Related
      ENSRNOP00000089441.1, ENSRNOT00000106385.2
      Conserved Domains (4) summary
      cd06878
      Location:594 → 716
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      pfam02194
      Location:148 → 303
      PXA; PXA domain
      pfam08628
      Location:793 → 899
      Nexin_C; Sorting nexin C terminal
      cl02565
      Location:437 → 545
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    3. XM_063275974.1 → XP_063132044.1  sorting nexin-25 isoform X3

      Related
      ENSRNOP00000103625.1, ENSRNOT00000155067.1

    4. XM_039094893.2 → XP_038950821.1  sorting nexin-25 isoform X4

      UniProtKB/TrEMBL
      Q5RJT4
      Conserved Domains (3) summary
      cd06878
      Location:273 → 395
      PX_SNX25; The phosphoinositide binding Phox Homology domain of Sorting Nexin 25
      pfam08628
      Location:472 → 578
      Nexin_C; Sorting nexin C terminal
      cl02565
      Location:62 → 170
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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