Megf6 multiple EGF-like-domains 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Megf6provided by RGD
Full Name: multiple EGF-like-domains 6provided by RGD
Primary source: RGD:621188
See related: EnsemblRapid:ENSRNOG00000000156 AllianceGenome:RGD:621188
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Egfl3
Summary: Predicted to enable calcium ion binding activity and scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in extracellular region. Orthologous to human MEGF6 (multiple EGF like domains 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 91.8), Thymus (RPKM 20.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (170020699..170121557)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (164738272..164839142)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (171588901..171620947)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: multiple epidermal growth factor-like domains protein 6

Names: EGF-like domain-containing protein 3; EGF-like-domain, multiple 3; epidermal growth factor-like protein 3; multiple EGF-like domain protein 3; multiple EGF-like domains protein 6; multiple epidermal growth factor-like domains 6; multiple epidermal growth factor-like domains protein 6-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022955.1 → NP_075244.1 multiple epidermal growth factor-like domains protein 6 precursor

See identical proteins and their annotated locations for NP_075244.1

Status: PROVISIONAL

Source sequence(s)

AB011532

UniProtKB/Swiss-Prot

O88281

Related

ENSRNOP00000000169.7, ENSRNOT00000000169.8

Conserved Domains (3) summary

pfam07546
Location:42 → 112

EMI; EMI domain

pfam14670
Location:338 → 373

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:154 → 202

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

170020699..170121557

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110728.1 → XP_038966656.1 multiple epidermal growth factor-like domains protein 6 isoform X1

Related

ENSRNOP00000108057.1, ENSRNOT00000149353.1

Conserved Domains (3) summary

pfam07546
Location:42 → 112

EMI; EMI domain

pfam14670
Location:127 → 162

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:243 → 284

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_039110730.1 → XP_038966658.1 multiple epidermal growth factor-like domains protein 6 isoform X2

UniProtKB/TrEMBL

D4AA94

Related

ENSRNOP00000052252.5, ENSRNOT00000055386.6

Conserved Domains (2) summary

pfam14670
Location:59 → 94

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:175 → 216

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...